Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans

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dc.authorid0000-0002-7638-0519
dc.authorid0000-0002-3875-2465
dc.authorid0000-0002-2107-1874
dc.authorid0000-0001-5824-6159
dc.authorid0000-0001-8256-9943
dc.authorid0000-0002-3781-6834
dc.authorscopusid57223189229
dc.authorscopusid57197854869
dc.authorscopusid57223181378
dc.authorscopusid57695047200
dc.authorscopusid16432686700
dc.authorscopusid12796269500
dc.authorscopusid56422040600
dc.contributor.authorTurna, Özge
dc.contributor.authorÜvez, Ayça
dc.contributor.authorBaykal, Aslıhan
dc.contributor.authorDeveli, Elif Sedef
dc.contributor.authorDıramalı, Murat
dc.contributor.authorSönmez, Kıvılcım
dc.contributor.authorKarakaş, Didem
dc.date.accessioned2024-09-25T19:42:57Z
dc.date.available2024-09-25T19:42:57Z
dc.date.issued2023
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractTumors are formed by various clones developed over a long time. This gives rise to a heterogeneous nature. This heterogeneity is the hardest challenge in the treatment of cancers because it is the main reason for drug resistance. This is a well-known fact in human cancer. Therefore, we have reasoned that if the tumor heterogeneity in canine mammary gland tumors (CMGTs) could be shown by an ex vivo assay, which will be used first time in veterinary oncology practice, this could be used further in clinics. To achieve this, twenty-six patients were included in the study. Tumor tissues were obtained from animals during routine surgery. Tumor cells were isolated and seeded ex vivo. The cells were exposed to anticancer drugs that are clinically used. Seven days after the treatment, chemosensitivity has luminometrically been assayed by ATP-tumor chemosensitivity assay (ATP-TCA). It has clearly been shown that all the tumor tissues have responded to treatment differently, implying that heterogeneity exists in mammary tumors. There has also been found that there was a weak to moderate statistically significant correlation between tumor size and drug index. However, there has been no correlation between drug index and metastasis to lymph nodes. Hyperplasic areas had relatively higher PCNA values. The results of our study demonstrate the heterogeneity in responses to in vitro drugs. Clinical trials based on test results and follow-up studies with large numbers of animals are needed to prove that such chemotherapeutic activity assessment tests can be clinically useful in predicting drug responses in CMGTs. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.en_US
dc.description.sponsorshipIstanbul Üniversitesi-Cerrahpasa, IÜC, (TSA-2018–28943)en_US
dc.identifier.doi10.1007/s11259-022-09934-3
dc.identifier.endpage120en_US
dc.identifier.issn0165-7380
dc.identifier.issue1en_US
dc.identifier.pmid35570257en_US
dc.identifier.scopus2-s2.0-85130110242en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1007/s11259-022-09934-3
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12380
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDıramalı, Murat
dc.institutionauthorid0000-0001-5824-6159
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media B.V.en_US
dc.relation.ispartofVeterinary Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectATP Assayen_US
dc.subjectCanineen_US
dc.subjectChemosensitivityen_US
dc.subjectChemotherapyen_US
dc.subjectMammary Tumoren_US
dc.titleEvidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humansen_US
dc.typeArticleen_US

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