The first electroanalytical study of umifenovir (Arbidol) used as a potential antiviral drug for the treatment of SARS-CoV-2: A voltammetric quantification on the boron-doped diamond electrode by using anionic surfactant media

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dc.authorid0000-0002-4428-2295en_US
dc.authorid0000-0003-1075-9574en_US
dc.authorid0000-0002-9587-096Xen_US
dc.contributor.authorÖzok, Hande İzem
dc.contributor.authorKıran, Musa
dc.contributor.authorYunusoğlu, Oruç
dc.contributor.authorYardım, Yavuz
dc.date.accessioned2024-02-05T11:12:43Z
dc.date.available2024-02-05T11:12:43Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionThe researchers would like to express their gratitude to the Van Yuzuncu Yil University's Scientific Research Projects Coordination Unit (BAP) Turkiye (Project number: FBA-2021-9426).en_US
dc.description.abstractIn this work, an electroanalytical procedure for sensing umifenovir (arbidol) by square wave adsorptive stripping voltammetry (SW-AdSV) was developed utilizing an anodically pretreated boron-doped diamond electrode. Measurements of umifenovir using cyclic voltammetry with phosphate buffer solution (PBS, 0.1 M, pH 2.5) revealed irreversible behaviour, adsorption-controlled as well as an ill-defined (+1.13 V, P-A1) and a well-defined (+1.47 V, P-A2) two oxidation peaks. Umifenovir oxidations depend critically on supporting electrolytes and pH. The second oxidation peak (P-A2) current of the umifenovir was enhanced by adding sodium dodecyl sulfate (SDS, anionic surfactant) in the chosen supporting electrolyte. Umifenovir was quantified using its second oxidation peak (P-A2) at about +1.39 V. Using the optimized condition, the oxidation peak current of P-A2 showed a linear relationship for umifenovir determination in the concentration range from 0.005 to 1.0 mu g ml(-1) (9.73 x 10(-9)-1.95 x 10(-6) M), with a detection limit of 0.0014 mu g ml(-1) (2.72 x 10(-9) M) in PBS (PH 2.5) with SDS. Finally, the developed approach was successfully utilized to determine umifenovir in the pharmaceutical formulation and urine samples. To the best of our knowledge, this is the first electroanalytical approach for voltammetric sensing of umifenovir.en_US
dc.description.sponsorshipVan Yuzuncu Yil University's Scientific Research Projects Coordination Unit (BAP) Turkiye [FBA-2021-9426]en_US
dc.identifier.citationÖzok, H. İ., Kıran, M., Yunusoğlu, O., & Yardım, Y. (2023). The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media. Journal of The Electrochemical Society, 170(1), 016501.en_US
dc.identifier.doi10.1149/1945-7111/acafa7
dc.identifier.issn0013-4651
dc.identifier.issn1945-7111
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85146370419en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.1149/1945-7111/acafa7
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11975
dc.identifier.volume170en_US
dc.identifier.wosWOS:000912142500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherElectrochemical Soc Incen_US
dc.relation.ispartofJournal of the Electrochemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlasmaen_US
dc.subjectSensing Umifenoviren_US
dc.subjectSW-AdSVen_US
dc.subjectSDSen_US
dc.subjectAnionic Surfactanten_US
dc.subjectOxidation Peaksen_US
dc.titleThe first electroanalytical study of umifenovir (Arbidol) used as a potential antiviral drug for the treatment of SARS-CoV-2: A voltammetric quantification on the boron-doped diamond electrode by using anionic surfactant mediaen_US
dc.typeArticleen_US

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