The first electroanalytical study of umifenovir (Arbidol) used as a potential antiviral drug for the treatment of SARS-CoV-2: A voltammetric quantification on the boron-doped diamond electrode by using anionic surfactant media
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Electrochemical Soc Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work, an electroanalytical procedure for sensing umifenovir (arbidol) by square wave adsorptive stripping voltammetry (SW-AdSV) was developed utilizing an anodically pretreated boron-doped diamond electrode. Measurements of umifenovir using cyclic voltammetry with phosphate buffer solution (PBS, 0.1 M, pH 2.5) revealed irreversible behaviour, adsorption-controlled as well as an ill-defined (+1.13 V, P-A1) and a well-defined (+1.47 V, P-A2) two oxidation peaks. Umifenovir oxidations depend critically on supporting electrolytes and pH. The second oxidation peak (P-A2) current of the umifenovir was enhanced by adding sodium dodecyl sulfate (SDS, anionic surfactant) in the chosen supporting electrolyte. Umifenovir was quantified using its second oxidation peak (P-A2) at about +1.39 V. Using the optimized condition, the oxidation peak current of P-A2 showed a linear relationship for umifenovir determination in the concentration range from 0.005 to 1.0 mu g ml(-1) (9.73 x 10(-9)-1.95 x 10(-6) M), with a detection limit of 0.0014 mu g ml(-1) (2.72 x 10(-9) M) in PBS (PH 2.5) with SDS. Finally, the developed approach was successfully utilized to determine umifenovir in the pharmaceutical formulation and urine samples. To the best of our knowledge, this is the first electroanalytical approach for voltammetric sensing of umifenovir.
Açıklama
The researchers would like to express their gratitude to the Van Yuzuncu Yil University's Scientific Research Projects Coordination Unit (BAP) Turkiye (Project number: FBA-2021-9426).
Anahtar Kelimeler
Plasma, Sensing Umifenovir, SW-AdSV, SDS, Anionic Surfactant, Oxidation Peaks
Kaynak
Journal of the Electrochemical Society
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
170
Sayı
1
Künye
Özok, H. İ., Kıran, M., Yunusoğlu, O., & Yardım, Y. (2023). The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media. Journal of The Electrochemical Society, 170(1), 016501.
