No association between polymorphism in the vascular endothelial growth factor gene at position-460 and sporadic prostate cancer in the Turkish population

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dc.contributor.authorÖnen, İlke H.
dc.contributor.authorKonaç, Ece
dc.contributor.authorEroğlu, Muzaffer
dc.contributor.authorGüneri, Çağrı
dc.contributor.authorBiri, Hasan
dc.contributor.authorEkmekçi, Abdullah
dc.date.accessioned2021-06-23T19:25:54Z
dc.date.available2021-06-23T19:25:54Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe development and progression of prostate cancer (PCa) has biologically and genetically remained a mystery. A man's risk of developing PCa is influenced by both genetic and environmental factors. Angiogenic cytokines like vascular endothelial growth factor (VEGF) play a pivotal role in tumor angiogenesis. Single nucleotide polymorphisms in angiogenesis-dependent genes affect the sensibility of cancer development and progression. Therefore, we hypothesized a potential association between DNA sequence variations in VEGF -460 gene region and sporadic PCa patients in the Turkish population. 133 sporadic PCa patients and 157 healthy controls were studied. Genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. The distribution of genotype and allele frequencies of the polymorphism did not yield a statistically significant difference between patients and controls (P > 0.05). Furthermore, classification of patients by tumor-lymph nodes-metastasis (TNM), Gleason Scores (GS) and serum prostate-specific antigen (PSA) levels did not show significant differences among the VEGF -460 C > T genotypes (P > 0.05). This is the first demonstration showing that the VEGF -460 C > T polymorphism in men is not associated with sporadic PCa in the Turkish population.en_US
dc.identifier.doi10.1007/s11033-006-9046-2
dc.identifier.endpage22en_US
dc.identifier.issn0301-4851
dc.identifier.issue1en_US
dc.identifier.pmid17216542en_US
dc.identifier.scopus2-s2.0-38349183079en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-006-9046-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6317
dc.identifier.volume35en_US
dc.identifier.wosWOS:000252541400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEroğlu, Muzaffer
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenotypingen_US
dc.subjectProstate Canceren_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.titleNo association between polymorphism in the vascular endothelial growth factor gene at position-460 and sporadic prostate cancer in the Turkish populationen_US
dc.typeArticleen_US

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