Matrix metalloproteinase-9 (MMP-9) in allergic nasal polyps

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0003-1691-618X
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorKaymakçı, Mustafa
dc.contributor.authorBukan, Neslihan
dc.date.accessioned2021-06-23T19:27:14Z
dc.date.available2021-06-23T19:27:14Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMatrix metalloproteinases (MMPs) are known to play important roles in the invasion of nasal mucosa by inflammatory cells through degradation of extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is considered to play a role in the pathogenesis of nasal polyp. The aim of the present study was to compare plasma MMP-9 levels of patients with nasal polyp of different etiologic origins, those with allergic nasal polyp (ANP) and non-allergic nasal polyp (NANP). In all, 29 patients (20 NANP and 9 ANP) and 20 healthy subjects were included in this study. Plasma MMP-9 levels were measured using ELISA. Plasma MMP-9 levels were higher (p<0.05) in ANP patients than in NANP patients and controls. In the group with ANP, plasma MMP-9 levels showed a positive correlation (p<0.05) with eosinophil counts. Plasma MMP-9 levels of NANP patients and control groups were similar (p>0.05). Moreover, that the highest levels of MMP-9 were in ANP patients may indicate the usefulness of this parameter in differentiating between the different etiologic origins of nasal polyp. Further studies are required to elaborate on the relationship between MMP-9 levels and allergic reactions. (C) 2008 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2008.07.002
dc.identifier.endpage95en_US
dc.identifier.issn0065-1281
dc.identifier.issue1en_US
dc.identifier.pmid18835014en_US
dc.identifier.scopus2-s2.0-73749085803en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2008.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6769
dc.identifier.volume112en_US
dc.identifier.wosWOS:000274528200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEdemaen_US
dc.subjectHumanen_US
dc.subjectInflammationen_US
dc.subjectNasal Mucosaen_US
dc.subjectNasal Polypen_US
dc.subjectMatrix Metalloproteinase-9en_US
dc.titleMatrix metalloproteinase-9 (MMP-9) in allergic nasal polypsen_US
dc.typeArticleen_US

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