Anti-genotoxic effect of oleuropein against aflatoxin B-1

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dc.authorid0000-0002-2795-8863en_US
dc.contributor.authorÇeker, Selçuk
dc.date.accessioned2023-06-05T12:29:01Z
dc.date.available2023-06-05T12:29:01Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThe author wish to thank Tuba AYDIN, assistant professor, for her help in isolating oleuropein. This study was supported by Agri Ibrahim Cecen University BAP (project no: ECZF.18.003).en_US
dc.description.abstractAflatoxin B-1 when binds to DNA bases, cause DNA damage, thus, affects the functioning, growth, division, and control of cells. Oleuropein is a fundamental polyphenol founded in olive leaf, fruit, oil and has many benefits for human health. In this study, the possible effect of oleuropein was assessed against toxicity of aflatoxin B-1. For this purpose, the single cell gel electrophoresis and micronuclei assays were performed using the cells of human peripheral blood. As a result of this study, it was determined that oleuropein has not genotoxic effect and exhibited anti-genotoxic properties caused by aflatoxin B1 (with especially 625 mu M application) (p<0.05). On this basis, the observed anti-genotoxic effect of oleuropein against aflatoxin B-1 may occur as oleuropein has sufficient capability to reduce the lipid peroxidation and inhibit the loss of membrane integrity.en_US
dc.description.sponsorshipAgri Ibrahim Cecen University BAP [ECZF.18.003]en_US
dc.identifier.citationCeker, S. (2021). ANTI-GENOTOXIC EFFECT OF OLEUROPEIN AGAINST AFLATOXIN B 1. Environmental Engineering & Management Journal (EEMJ), 20(11).en_US
dc.identifier.endpage1750en_US
dc.identifier.issn1582-9596
dc.identifier.issn1843-3707
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1745en_US
dc.identifier.urihttp://www.eemj.icpm.tuiasi.ro/pdfs/vol20/no11/Full/5_590_Ceker_20.pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11063
dc.identifier.volume20en_US
dc.identifier.wosWOS:000740259300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇeker, Selçuk
dc.language.isoenen_US
dc.publisherGheorghe Asachi Technical University of Iasien_US
dc.relation.ispartofEnvironmental Engineering and Management Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAflatoxin B-1en_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectComet Assayen_US
dc.subjectMicronuclei Assayen_US
dc.titleAnti-genotoxic effect of oleuropein against aflatoxin B-1en_US
dc.typeArticleen_US

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