Anti-genotoxic effect of oleuropein against aflatoxin B-1

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Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Gheorghe Asachi Technical University of Iasi

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Aflatoxin B-1 when binds to DNA bases, cause DNA damage, thus, affects the functioning, growth, division, and control of cells. Oleuropein is a fundamental polyphenol founded in olive leaf, fruit, oil and has many benefits for human health. In this study, the possible effect of oleuropein was assessed against toxicity of aflatoxin B-1. For this purpose, the single cell gel electrophoresis and micronuclei assays were performed using the cells of human peripheral blood. As a result of this study, it was determined that oleuropein has not genotoxic effect and exhibited anti-genotoxic properties caused by aflatoxin B1 (with especially 625 mu M application) (p<0.05). On this basis, the observed anti-genotoxic effect of oleuropein against aflatoxin B-1 may occur as oleuropein has sufficient capability to reduce the lipid peroxidation and inhibit the loss of membrane integrity.

Açıklama

The author wish to thank Tuba AYDIN, assistant professor, for her help in isolating oleuropein. This study was supported by Agri Ibrahim Cecen University BAP (project no: ECZF.18.003).

Anahtar Kelimeler

Aflatoxin B-1, Carbonic Anhydrase, Comet Assay, Micronuclei Assay

Kaynak

Environmental Engineering and Management Journal

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

20

Sayı

11

Künye

Ceker, S. (2021). ANTI-GENOTOXIC EFFECT OF OLEUROPEIN AGAINST AFLATOXIN B 1. Environmental Engineering & Management Journal (EEMJ), 20(11).