Anti-genotoxic effect of oleuropein against aflatoxin B-1
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gheorghe Asachi Technical University of Iasi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aflatoxin B-1 when binds to DNA bases, cause DNA damage, thus, affects the functioning, growth, division, and control of cells. Oleuropein is a fundamental polyphenol founded in olive leaf, fruit, oil and has many benefits for human health. In this study, the possible effect of oleuropein was assessed against toxicity of aflatoxin B-1. For this purpose, the single cell gel electrophoresis and micronuclei assays were performed using the cells of human peripheral blood. As a result of this study, it was determined that oleuropein has not genotoxic effect and exhibited anti-genotoxic properties caused by aflatoxin B1 (with especially 625 mu M application) (p<0.05). On this basis, the observed anti-genotoxic effect of oleuropein against aflatoxin B-1 may occur as oleuropein has sufficient capability to reduce the lipid peroxidation and inhibit the loss of membrane integrity.
Açıklama
The author wish to thank Tuba AYDIN, assistant professor, for her help in isolating oleuropein. This study was supported by Agri Ibrahim Cecen University BAP (project no: ECZF.18.003).
Anahtar Kelimeler
Aflatoxin B-1, Carbonic Anhydrase, Comet Assay, Micronuclei Assay
Kaynak
Environmental Engineering and Management Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
20
Sayı
11
Künye
Ceker, S. (2021). ANTI-GENOTOXIC EFFECT OF OLEUROPEIN AGAINST AFLATOXIN B 1. Environmental Engineering & Management Journal (EEMJ), 20(11).
