Effect of prophylactic intraocular pressure-lowering medication on pain during cataract surgery

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dc.authorid0000-0003-4468-3985en_US
dc.contributor.authorUlaş, Fatih
dc.contributor.authorBalbaba, Mehmet
dc.contributor.authorÇelebi, Serdal
dc.date.accessioned2021-06-23T19:34:16Z
dc.date.available2021-06-23T19:34:16Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: This study evaluated the effects of acetazolamide, latanoprost, travoprost, bimatoprost, brimonidine, brinzolamide, and timolol on pain during phacoemulsification cataract surgery. Methods: This prospective randomized comparative study included 323 eyes of 323 patients with no history of intraocular surgery or chronic eye disease who underwent uncomplicated phacoemulsification cataract surgery and foldable intraocular lens implantation under topical anesthesia. Patients were divided into 8 groups according to the preoperative prophylactic intraocular pressure (IOP)-lowering medication. The intraoperative pain was assessed postoperatively using a visual analog pain scale. The Kruskal-Wallis test investigated the differences in the visual analog pain-scale scores of the groups, and the Mann-Whitney U test investigated the pairwise comparison of the groups. Results: The median visual analog pain-scale score of the group that did not receive any IOP-lowering medication was 2.0 +/- 1.89. The brimonidine group exhibited the lowest visual analog pain-scale scores, and the prostanoids, especially the bimatoprost group, demonstrated the highest visual analog pain-scale scores (median +/- standard deviation were 0.0 +/- 1.50 and 2.0 +/- 1.91, respectively). The median visual analog pain-scale scores of the acetazolamide, latanoprost, travoprost, brinzolamide, and timolol groups were 0.0 +/- 1.62, 2.0 +/- 1.67, 2.0 +/- 1.73, 0.0 +/- 1.66, and 1.0 +/- 1.54, respectively. A pairwise comparison using the Mann-Whitney U test with Bonferroni correction revealed significant differences between the groups of acetozolamide and travoprost (p = 0.001), acetozolamide and bimatoprost (p < 0.001), travoprost and brimonidine (p < 0.001), bimatoprost and brimonidine (p < 0.001), and bimatoprost and timolol (p = 0.001). Conclusions: Prophylactic application of the IOP-lowering medication may alter the pain sensation during phacoemulsification cataract surgery.en_US
dc.identifier.doi10.1089/jop.2012.0244
dc.identifier.endpage662en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue7en_US
dc.identifier.pmid23461283en_US
dc.identifier.scopus2-s2.0-84883288354en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage658en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2012.0244
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7447
dc.identifier.volume29en_US
dc.identifier.wosWOS:000339268700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlaş, Fatih
dc.institutionauthorÇelebi, Serdal
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of prophylactic intraocular pressure-lowering medication on pain during cataract surgeryen_US
dc.typeArticleen_US

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