The clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG)

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dc.authorid0000-0002-6839-2632en_US
dc.authorid0000-0003-1043-8105en_US
dc.authorid0000-0002-0598-7284
dc.authorid0000-0002-4034-1614
dc.authorid0000-0002-4351-0065
dc.authorid0000-0002-5974-6339
dc.authorid0000-0002-2756-8646
dc.authorid0000-0001-9668-757X
dc.contributor.authorTanrıverdi, Özgür
dc.contributor.authorKaytan-Sağlam, Esra
dc.contributor.authorÜlger, Şükran
dc.contributor.authorBayoğlu, İbrahim Vedat
dc.contributor.authorTürker, İbrahim
dc.contributor.authorÖztürk-Topçu, Türkan
dc.contributor.authorÇokmert, Suna
dc.contributor.authorTurhal, Serdal
dc.contributor.authorOktay, Esin
dc.contributor.authorKarabulut, Bülent
dc.contributor.authorKılıç, Diclehan
dc.contributor.authorKüçükzeybek, Yüksel
dc.contributor.authorÖksüzoğlu, Berna
dc.contributor.authorMeydan, Nezih
dc.contributor.authorKaya, Vildan
dc.contributor.authorAkman, Tülay
dc.contributor.authorİbiş, Kamuran
dc.contributor.authorSağnak, Mert
dc.contributor.authorŞen, Cenk Ahmet
dc.contributor.authorUysal-Sönmez, Özlem
dc.contributor.authorPilancı, Kezban Nur
dc.contributor.authorDemir, Gökhan
dc.contributor.authorSağlam, Sezer
dc.contributor.authorKoçar, Muharrem
dc.contributor.authorMenekşe, Serkan
dc.contributor.authorGöksel, Gamze
dc.contributor.authorYapar-Taşköylü, Burcu
dc.contributor.authorYaren, Arzu
dc.contributor.authorÜyetürk, Ümmügül
dc.date.accessioned2021-06-23T19:35:38Z
dc.date.available2021-06-23T19:35:38Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBrain metastasis in colorectal cancer is highly rare. In the present study, we aimed to determine the frequency of brain metastasis in colorectal cancer patients and to establish prognostic characteristics of colorectal cancer patients with brain metastasis. In this cross-sectional study, the medical files of colorectal cancer patients with brain metastases who were definitely diagnosed by histopathologically were retrospectively reviewed. Brain metastasis was detected in 2.7 % (n = 133) of 4,864 colorectal cancer patients. The majority of cases were male (53 %), older than 65 years (59 %), with rectum cancer (56 %), a poorly differentiated tumor (70 %); had adenocarcinoma histology (97 %), and metachronous metastasis (86 %); received chemotherapy at least once for metastatic disease before brain metastasis developed (72 %), had progression with lung metastasis before (51 %), and 26 % (n = 31) of patients with extracranial disease at time the diagnosis of brain metastasis had both lung and bone metastases. The mean follow-up duration was 51 months (range 5-92), and the mean survival was 25.8 months (95 % CI 20.4-29.3). Overall survival rates were 81 % in the first year, 42.3 % in the third year, and 15.7 % in the fifth year. In multiple variable analysis, the most important independent risk factor for overall survival was determined as the presence of lung metastasis (HR 1.43, 95 % CI 1.27-4.14; P = 0.012). Brain metastasis develops late in the period of colorectal cancer and prognosis in these patients is poor. However, early screening of brain metastases in patients with lung metastasis may improve survival outcomes with new treatment modalities.en_US
dc.identifier.doi10.1007/s12032-014-0152-z
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue9en_US
dc.identifier.pmid25108599en_US
dc.identifier.scopus2-s2.0-84905298096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-014-0152-z
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7836
dc.identifier.volume31en_US
dc.identifier.wosWOS:000341835700025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Ümmügül
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectBrain Metastasisen_US
dc.subjectPrognosisen_US
dc.titleThe clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG)en_US
dc.typeArticleen_US

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