Prospective epidemiologic evidence of a "protective" effect of smoking on metabolic syndrome and diabetes among Turkish women-without associated overall health benefit

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dc.authorid0000-0002-2001-9142en_US
dc.contributor.authorOnat, Altan
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorEsen, A. Metin
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorKarabulut, Ahmet
dc.date.accessioned2021-06-23T19:20:01Z
dc.date.available2021-06-23T19:20:01Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSex-specific effects of cigarette smoking on the development of metabolic syndrome (MS) and diabetes (DM), concomitant with its clinical impact on CHD, were prospectively evaluated in a cohort of 3385 participants (mean age 48 years), representative of Turks. Heavy smoking denoted smoking 11 or more cigarettes daily. During a mean 5.9-year follow-up, 485 incident cases of MS and 216 of DM were diagnosed. Among women, baseline characteristics as a whole were similar. Smoking status was inversely associated with waist circumference (P = 0.004) and predicted in women hyperinsulinemia (p = 0.045) after adjustment for age and body mass index. In the prediction of MS, heavy smoking was significantly "protective" (RR 0.50 [95% CI 0.26; 0.94]) in women and in both genders combined, after adjustment for age, baseline family income bracket and physical activity grade. As predictor of new DM, heavy smoking was significantly "protective" (RR 0.54 (95% CI 0.35; 0.83]) in all adults and in women (RR 0. 13 [95% CI 0.02; 0.97]), after similar adjustment. Additional adjustment for insulin and CRP levels hardly modified in women the RRs, though attenuated to borderline significance risk for MS and DM due to smaller sample size. Risks of incident CHD and overall mortality were significantly elevated in smoking men, but not in women, when adjusted for age, serum total cholesterol, elevated BP, DM and physical activity grade. Conclusions: Heavy cigarette smoking is "protective" of future MS and DM in Turkish women, mainly via protection from obesity. A separate modest effect on central obesity appeared independent of plasma insulin concentrations. Evidence of a translated beneficial effect on subsequent CHD or all-cause mortality did not emerge. (c) 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.atherosclerosis.2006.07.002
dc.identifier.endpage388en_US
dc.identifier.issn0021-9150
dc.identifier.issn1879-1484
dc.identifier.issue2en_US
dc.identifier.pmid16926017en_US
dc.identifier.scopus2-s2.0-34447319111en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage380en_US
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2006.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6044
dc.identifier.volume193en_US
dc.identifier.wosWOS:000248961200019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzhan, Hakan
dc.institutionauthorAlbayrak, Sinan
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofAtherosclerosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbdominal Obesityen_US
dc.subjectCigarette Smokingen_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectDiabetes Type 2en_US
dc.subjectMetabolic Syndromeen_US
dc.subjectProinflammatory Stateen_US
dc.subjectProspective Population-based Studyen_US
dc.titleProspective epidemiologic evidence of a "protective" effect of smoking on metabolic syndrome and diabetes among Turkish women-without associated overall health benefiten_US
dc.typeArticleen_US

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