C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: The clear hep-c study

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dc.authorid0000-0001-6262-6103en_US
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-3836-2125en_US
dc.contributor.authorDemirkol, Muhammed Emin
dc.contributor.authorAktaş, Gülali
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorKahveci, Gizem
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.date.accessioned2023-11-27T07:43:22Z
dc.date.available2023-11-27T07:43:22Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: Chronic hepatitis C (CHC) is one of the most important health problems affecting the significant rate of world population and it may lead to cirrhosis and hepatocellular carcinoma. C-reactive protein to lymphocyte count ratio (CLR) is used in estimating inflammatory burden. Therefore, this study aimed to compare CLR values between CHC patients and healthy controls and between CHC patients with and without fibrosis. METHODS: Patients with CHC infection who visited outpatient and inpatient internal medicine clinics of our institution between January 2021 and December 2021 were enrolled to this retrospective study. CLR of the patients with CHC and healthy controls were compared. We further compared CLR of CHC patients with and without fibrosis. RESULTS: Median CLR of CHC and control subjects was 2.61 (5.13%) and 0.31 (0.37%), respectively. CLR of the CHC group was significantly increased compared to the CLR of the controls (p<0.001). There was a significant positive correlation between CLR and APRI score (r=0.15, p=0.04). The sensitivity and specificity of CLR in determining CHC above 0.58% level were 84% and 82%, respectively (AUC: 0.884, p<0.001, 95%CI 0.84- 0.93). In subgroup analysis, CLR was 3.97 (6.6%) for CHC patients with fibrosis and 1.7 (4.4%) for CHC subjects without fibrosis (p=0.001). CONCLUSIONS: Increased CLR in patients with CHC may be an alarming finding of liver fibrosis, as CLR is associated with both CHC and hepatic fibrosis.en_US
dc.identifier.citationDemirkol, M. E., Aktas, G., Bilgin, S., Kahveci, G., Kurtkulagi, O., Atak, B. M., & Duman, T. T. (2022). C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study. Revista da Associação Médica Brasileira, 68, 838-841.en_US
dc.identifier.doi10.1590/1806-9282.20220236
dc.identifier.endpage841en_US
dc.identifier.issn1806-9282
dc.identifier.issue6en_US
dc.identifier.pmid35766701en_US
dc.identifier.scopus2-s2.0-85133213991en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage838en_US
dc.identifier.urihttp://dx.doi.org/10.1590/1806-9282.20220236
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11885
dc.identifier.volume68en_US
dc.identifier.wosWOS:000823735900025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemirkol, Muhammed Emin
dc.institutionauthorAktaş, Gülali
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.language.isoenen_US
dc.publisherAssociação Médica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectChronic Hepatitis Cen_US
dc.subjectFibrosisen_US
dc.subjectC-Reactive Protein to Lymphocyte Count Ratioen_US
dc.subjectClinical-Significanceen_US
dc.titleC-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: The clear hep-c studyen_US
dc.typeArticleen_US

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