Mitochondrial metabolism related markers GDF-15, FGF-21, and HIF-1a are elevated in pediatric migraine attacks

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dc.authorid0000-0002-1795-5677en_US
dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0003-0962-2116en_US
dc.authorid0000-0002-1019-9207en_US
dc.authorid0000-0001-6002-052Xen_US
dc.authorid0000-0003-2797-2398en_US
dc.contributor.authorKılınç, Yasemin Baranoğlu
dc.contributor.authorKılınç, Erkan
dc.contributor.authorDanış, Aysegül
dc.contributor.authorHancı, Fatma
dc.contributor.authorTüray, Sevim
dc.contributor.authorÖzge, Aynur
dc.date.accessioned2024-05-28T11:07:00Z
dc.date.available2024-05-28T11:07:00Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionGazi University, Grant/Award Number: TGA-2022-7857; Turkish Academy of Sciences (TUBA)en_US
dc.description.abstractObjective: The purpose of this study was to investigate the serum levels of mitochon-drial metabolism/reactive oxygen species (ROS)- related peptides (hypoxia induc-ible factor- 1a [HIF- 1a], fibroblast growth factor -21 [FGF- 21], growth differentiation factor -15 [GDF- 15]) and key migraine- related neuropeptides (calcitonin gene- related peptide [CGRP], pituitary adenylate cyclase- activating peptide -38 [PACAP- 38], sub-stance P [SP], and vasoactive intestinal peptide [VIP]) during migraine attacks and to evaluate their diagnostic value in pediatric migraine.Background: There is increasing evidence for the important role of impairment in oxidative mitochondrial metabolism in the pathophysiology of migraine. Potential biomarkers that may reflect the relationship between migraine and mitochondrial dysfunction are unclear.Methods: A total of 68 female pediatric migraine patients without aura and 20 fe -male healthy controls aged 8- 18 years, admitted to the hospital, were enrolled in this cross- sectional study. Serum concentrations of these molecules were determined by enzyme- linked immunosorbent assays, and clinical features and their possible diag-nostic value were analyzed.Results: Serum levels of HIF- 1a (252.4 +/- 51.9 [mean +/- standard deviation]) pg/mL), GDF- 15 (233.7 +/- 24.7 pg/mL), FGF- 21 (96.1 +/- 13.1 pg/mL), CGRP (44.5 +/- 11.3), and PACAP- 38 (504.7 +/- 128.9) were significantly higher in migraine patients compared to healthy controls (199.8 +/- 26.8, 192.8 +/- 20.7, 79.3 +/- 4.1, 34.1 +/- 3.5 and 361.2 +/- 86.3 pg/ mL, respectively). The serum levels of these peptides were also higher in patients with chronic migraine than in patients with episodic migraine, and higher in the ictal period than in the interictal period. A positive correlation was found between attack frequency and both HIF- 1a and FGF- 21 levels in migraine patients. Serum levels of VIP and SP were not different between the migraine patients and healthy controls.Conclusion: Migraine attacks are accompanied by elevated HIF- 1a, FGF- 21, GDF- 15, CGRP, and PACAP- 38 in medication -naive pediatric patients with migraine. Elevated circulating mitochondrial metabolism/ROS-related peptides suggest a mitochondrial stress in pediatric migraine attacks and may have potential diagnostic value in monitoring disease progression and treatment response in children. Novel approaches intervening with mitochondrial metabolism need to be investigated.en_US
dc.description.sponsorshipGazi University [TGA-2022-7857]; Turkish Academy of Sciences (TUBA)en_US
dc.identifier.citationKilinc, Y. B., Kilinc, E., Danis, A., Hanci, F., Turay, S., Ozge, A., & Bolay, H. (2023). Mitochondrial metabolism related markers GDF‐15, FGF‐21, and HIF‐1α are elevated in pediatric migraine attacks. Headache: The Journal of Head and Face Pain, 63(8), 1076-1086.en_US
dc.identifier.doi10.1111/head.14618
dc.identifier.endpage1086en_US
dc.identifier.issn0017-8748
dc.identifier.issn1526-4610
dc.identifier.pmid37596867en_US
dc.identifier.scopus2-s2.0-85168351269en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1076en_US
dc.identifier.urihttp://dx.doi.org/10.1111/head.14618
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12175
dc.identifier.volume63en_US
dc.identifier.wosWOS:001051141900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılınç, Erkan
dc.institutionauthorHancı, Fatma
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHeadacheen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFGF-21en_US
dc.subjectGDF-15en_US
dc.subjectHIF-1 & Alphaen_US
dc.subjectMitochondrial Metabolismen_US
dc.subjectPediatric Migraineen_US
dc.subjectVasoactive Neuropeptidesen_US
dc.titleMitochondrial metabolism related markers GDF-15, FGF-21, and HIF-1a are elevated in pediatric migraine attacksen_US
dc.typeArticleen_US

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