The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver

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dc.authorid0000-0002-2635-7011en_US
dc.authorid0000-0002-4133-407Xen_US
dc.authorid0000-0002-6949-9191
dc.authorid0000-0002-8754-2528
dc.authorid0000-0001-5073-0691
dc.authorid0000-0001-5387-2628
dc.authorid0000-0001-6872-621X
dc.contributor.authorBozcaarmutlu, Azra
dc.contributor.authorSapmaz, Canan
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorKükner, Aysel
dc.contributor.authorKılınç, Leyla
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorÖzarslan, Oğulcan Talat
dc.contributor.authorEkşioğlu, Didem
dc.date.accessioned2021-06-23T19:17:10Z
dc.date.available2021-06-23T19:17:10Z
dc.date.issued2020
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractIt is possible to use plant-derived antioxidant molecules in the form of dietary supplements. However, dietary supplement-drug interaction pattern has not been well defined for most of these products. The aim of this study was to determine the effects of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rats. Streptozotocin was administered to create experimental diabetes. Resveratrol (5 mg/kg) (R), glibenclamide (5 mg/kg) (G), and berberine (10 mg/kg) (B) were administered individually or in combinations in DMSO by intraperitoneal administration route to the diabetic rats. DMSO was also given to non-diabetic control (C) and diabetic control (D) groups. Livers of rats were taken under anesthesia at the end of the treatment period (12 days). Ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-depentylase (PROD), aniline 4-hydroxylase (A4H), erythromycin N-demethylase (ERND), glutathione S-transferase (GST), catalase (CAT), and glutathione reductase (GR) activities were measured in microsomes and cytosols. In addition, histomorphological studies were also performed in the liver tissues. EROD activity of D+R was significantly higher than C and D+R+B. PROD activity of D+R was significantly higher than C, D, D+R+G, D+R+B, and D+R+B+ G. PROD activity of D+B was significantly higher than C and D+R+B. ERND activity of D+R was significantly higher than D+R+G and D+R+B. GST activity of D+R was significantly higher than D+R+G. CAT activity of D+B was significantly lower than C. It is clear that co-administration of resveratrol, berberine, and glibenclamide modifies some of the important xenobiotic metabolizing enzyme activities. Resveratrol and berberine have the potential to cause dietary supplement-drug interaction.en_US
dc.identifier.doi10.1080/01480545.2020.1802475
dc.identifier.endpage998
dc.identifier.issn0148-0545
dc.identifier.issue3
dc.identifier.pmid32762264en_US
dc.identifier.scopus2-s2.0-85089190247en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage990
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1802475
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5262
dc.identifier.volume45
dc.identifier.wosWOS:000556467400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozcaarmutlu, Azra
dc.institutionauthorSapmaz, Canan
dc.institutionauthorEkşioğlu, Didem
dc.institutionauthorÖzarslan, Oğulcan Talat
dc.institutionauthorBozdoğan, Ömer
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytochrome P450en_US
dc.subjectDiabetesen_US
dc.subjectBerberineen_US
dc.subjectGlibenclamideen_US
dc.subjectResveratrolen_US
dc.subjectXenobiotic Metabolizing Enzymeen_US
dc.titleThe effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liveren_US
dc.typeArticleen_US

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