Validation of the HCC-RESCUE score to predict hepatocellular carcinoma risk in Caucasian chronic hepatitis B patients under entecavir or tenofovir therapy

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dc.authorid0000-0003-4889-208Xen_US
dc.authorid0000-0003-2157-0304en_US
dc.authorid0000-0002-6054-9244en_US
dc.authorid0000-0002-1979-9145en_US
dc.contributor.authorGüzelbulut, Fatih
dc.contributor.authorGökçen, Pınar
dc.contributor.authorCan, Güray
dc.contributor.authorAdalı, Gupse
dc.contributor.authorSaltürk, Ayça Gökçen Değirmenci
dc.date.accessioned2023-07-17T12:25:06Z
dc.date.available2023-07-17T12:25:06Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe HCC-RESCUE score was developed to predict hepatocellular carcinoma (HCC) risk in Korean chronic hepatitis B (CHB) patients under entecavir therapy. We aimed to validate the HCC-RESCUE score to predict HCC risk in Caucasian CHB patients under entecavir or tenofovir therapy and to compare the predictive performance of the HCC-RESCUE score with those of the CAMD, PAGE-B and modified PAGE-B (mPAGE-B) scores. The study included 647 nucleos(t)ide analogue-naive noncirrhotic and compensated/decompensated cirrhotic patients who had received entecavir or tenofovir for >= 6 months and did not develop HCC during the first 6 months of therapy. Patients with HCC-RESCUE scores <= 64, 65-84 and >= 85 points were classified into low-, intermediate- and high-risk groups, respectively. The AUROCs of the HCC-RESCUE, CAMD, PAGE-B and mPAGE-B scores to predict HCC risk at 5 years were 0.875, 0.870, 0.866 and 0.880, and those at 10 years were 0.862, 0.845, 0.841 and 0.862, respectively (both p > .05). Cumulative HCC incidences at 5 years were 0.0%, 10.5% and 15.8%, and those at 10 years were 1.4%, 15.5% and 24.9%, respectively, in the low-, intermediate- and high-risk groups based on the HCC-RESCUE score (both log rank p < .001). In the entecavir versus tenofovir cohorts, the AUROCs of the HCC-RESCUE score to predict HCC risk at 5 and 10 years were 0.831 versus 0.898 and 0.803 versus 0.910, respectively (both p > .05). The HCC-RESCUE score accurately predicted HCC risk in Caucasian CHB patients under entecavir or tenofovir therapy. A substantial proportion of patients can be dropped from HCC surveillance by using the HCC-RESCUE score.en_US
dc.identifier.citationGüzelbulut, F., Gökçen, P., Can, G., Adalı, G., Değirmenci Saltürk, A. G., Bahadır, Ö., ... & Doğanay, H. L. (2021). Validation of the HCC‐RESCUE score to predict hepatocellular carcinoma risk in Caucasian chronic hepatitis B patients under entecavir or tenofovir therapy. Journal of Viral Hepatitis, 28(5), 826-836.en_US
dc.identifier.doi10.1111/jvh.13485
dc.identifier.endpage836en_US
dc.identifier.issn1352-0504
dc.identifier.issn1365-2893
dc.identifier.issue5en_US
dc.identifier.pmid33586270en_US
dc.identifier.scopus2-s2.0-85101935713en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage826en_US
dc.identifier.urihttp://dx.doi.org/10.1111/jvh.13485
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11301
dc.identifier.volume28en_US
dc.identifier.wosWOS:000621124200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCan, Güray
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJournal of Viral Hepatitisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectRisk Predictionen_US
dc.subjectHCC-RESCUEen_US
dc.titleValidation of the HCC-RESCUE score to predict hepatocellular carcinoma risk in Caucasian chronic hepatitis B patients under entecavir or tenofovir therapyen_US
dc.typeArticleen_US

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