Could plasma D-dimer levels be a predictive marker for prognosis in lung cancer?

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dc.authorid0000-0002-3495-2339
dc.authorid0000-0002-4641-2866
dc.contributor.authorKurt, Bahar
dc.contributor.authorKar Kurt, Özlem
dc.contributor.authorKalaycı, Defne
dc.contributor.authorTuğ, Tuncer
dc.contributor.authorTalay, Fahrettin
dc.date.accessioned2021-06-23T18:55:40Z
dc.date.available2021-06-23T18:55:40Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Plasma concentrations of circulatory markers of hemostatic activation which may be associated with tumor growth and dissemination have been shown to predict prognosis in malignancy. The present study was designed to investigate the prognostic value of plasma D-dimer level in lung cancer. Materials and Methods: Plasma levels of the D-dimer in 138 lung cancer patients [98 non-small cell lung cancer (NSCLC), 40 small cell lung cancer (SCLC)] were measured before the initiation of any therapy and each chemotherapy. Results: There were 124 (89.9%) men and 14 (10.1%) women with a mean age of 62.8 years (range 38-84). There were no statistically significant differences among the histopathologic types for NSCLC patients. Stage IIIA NSCLC group had statistically significant higher D-dimer level than stages I-II and IV. D-dimer levels were increased significantly after 4 cycles of chemotherapy in progressive disease. The median survival times in NSCLC patients were 26.6 months (95% CI, 17.6-35.6) and 15.9 months (95% CI, 4.2-27.7; p= 0.037) respectively, for patients with a low D-dimer level (? 1.2 ng/L) and a high D-dimer level (> 1.2 ng/L).With the cox-regression analysis, the plasma level of D-dimer and tumour stage were identified as independent predictive factors of the survival. Conclusion: These results suggest that plasmalevel of D-dimer can act as a predictive factor of decreased survival and a poor response to the treatment in lung cancer.en_US
dc.identifier.doi10.5578/tt.6128
dc.identifier.endpage274en_US
dc.identifier.issn0494-1373
dc.identifier.issue4en_US
dc.identifier.pmid24506741en_US
dc.identifier.scopus2-s2.0-84896702076en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://doi.org/10.5578/tt.6128
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4831
dc.identifier.volume61en_US
dc.identifier.wosWOS:000421335500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Bahar
dc.institutionauthorKar Kurt, Özlem
dc.institutionauthorKalaycı, Defne
dc.institutionauthorTuğ, Tuncer
dc.institutionauthorTalay, Fahrettin
dc.language.isoenen_US
dc.relation.ispartofTuberkuloz ve Toraksen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectD-dimeren_US
dc.subjectLung Canceren_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titleCould plasma D-dimer levels be a predictive marker for prognosis in lung cancer?en_US
dc.title.alternativePlazma D-dimer düzeyleri akciğer kanserinde prognoz için bir belirteç olabilir mi?en_US
dc.typeArticleen_US

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