The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: The abund study

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dc.authorid0000-0002-3172-8200en_US
dc.authorid0000-0002-4162-5563en_US
dc.authorid0000-0003-4520-4085en_US
dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0003-4201-9757en_US
dc.authorid0000-0003-2811-0052en_US
dc.authorid0000-0001-6262-6103en_US
dc.authorid0000-0001-7306-5233en_US
dc.contributor.authorKösekli, Mehmet Ali
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorKahveci, Gizem
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorTel, Burçin Meryem Atak
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorDemirkol, Muhammed Emin
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2023-05-31T13:15:18Z
dc.date.available2023-05-31T13:15:18Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: Non- alcoholic fatty liver disease, which is characterized by lipid being deposited into hepatocytes, affects nearly one in three adults globally. Inflammatory markers were suggested to be related with hepatic steatosis. Uric acid to HDL cholesterol ratio is proposed as a novel inflammatory and metabolic marker. We aimed to compare Uric acid to HDL cholesterol ratio levels of patients with Non-alcoholic fatty liver disease to those of healthy controls and find out potential correlations between Uric acid to HDL cholesterol ratio and other inflammatory and metabolic markers of Non-alcoholic fatty liver disease. METHODS: Patients with a diagnosis of Non-alcoholic fatty liver disease who were on clinical follow-up in our institution were enrolled in the study as the Non- alcoholic fatty liver disease group, while healthy volunteers were enrolled as the control group. The Uric acid to HDL cholesterol ratio of the groups was compared and potential correlations were studied between Uric acid to HDL cholesterol ratio and fasting blood glucose, transaminases, serum lipids (triglyceride, LDL- cholesterol), weight, and body mass index. RESULTS: The Uric acid to HDL cholesterol ratio of the Non-alcoholic fatty liver disease (13 +/- 5%) group was significantly higher compared to the Uric acid to HDL cholesterol ratio of the control (10 +/- 4%) group (p<0.001). Uric acid to HDL cholesterol ratio was significantly and positively correlated with fasting blood glucose, transaminases, triglyceride, body weight, waist circumference, hip circumference, and body mass index. A ROC analysis revealed that a Uric acid to HDL cholesterol ratio level greater than 9.6% has 73% sensitivity and 51% specificity in determining Non-alcoholic fatty liver disease. CONCLUSION: Due to the inexpensive and easy-to-assess nature of Uric acid to HDL cholesterol ratio, we suggest that elevated Uric acid to HDL cholesterol ratio levels be considered a useful tool in diagnosing hepatic steatosis.en_US
dc.identifier.citationKosekli, M. A., Kurtkulagii, O., Kahveci, G., Duman, T. T., Tel, B. M. A., Bilgin, S., ... & Aktas, G. (2021). The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. Revista da Associação Médica Brasileira, 67, 549-554.en_US
dc.identifier.doi10.1590/1806-9282.20201005
dc.identifier.endpage554en_US
dc.identifier.issn1806-9282
dc.identifier.issue4en_US
dc.identifier.pmid34495059en_US
dc.identifier.scopus2-s2.0-85114410351en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage549en_US
dc.identifier.urihttp://dx.doi.org/10.1590/1806-9282.20201005
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11036
dc.identifier.volume67en_US
dc.identifier.wosWOS:000692950900015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKösekli, Mehmet Ali
dc.institutionauthorKurtkulağı, Özge
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorDemirkol, Muhammed Emin
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherAssociação Médica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectLiver Steatosisen_US
dc.subjectUric Aciden_US
dc.subjectHDL Cholesterolen_US
dc.titleThe association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: The abund studyen_US
dc.typeArticleen_US

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