Relationship between angiotensin-converting enzyme gene polymorphism and QT dispersion in hemodialysis patients

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dc.authorid0000-0003-2290-3342
dc.authorid0000-0002-4542-4064
dc.authorid0000-0002-0972-8896
dc.contributor.authorToraman, Aysun
dc.contributor.authorÇolak, Hülya
dc.contributor.authorTekçe, Hikmet
dc.contributor.authorCam, Sırrı
dc.contributor.authorKürşat, Seyhun
dc.date.accessioned2021-06-23T19:48:54Z
dc.date.available2021-06-23T19:48:54Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction. The angiotensin-converting enzyme (ACE) gene insertion or deletion in long-term hemodialysis patients may be associated with corrected QT interval prolongation, leading to fatal arrhythmias. The ACE D allele is known to increase the risk of malignant ventricular arrhythmias and is also associated with increased QT dispersion after myocardial infarction and hypertension. This study aimed to evaluate the relationship between ACE gene polymorphism and QT dispersion in hemodialysis patients. Materials and Methods. In 70 hemodialysis patients, electrocardiography was performed and QT dispersion was calculated. Corrected QT interval was calculated using Bazett Formula. The ACE gene polymorphism was determined by polymerase chain reaction. Results. The mean age of the patients was 60 +/- 12 years. The mean QT dispersion and corrected QT dispersion were 61.71 +/- 21.99 and 73.18 +/- 25.51, respectively. QT dispersion inversely correlated with serum calcium and potassium levels and positively correlated with ACE gene polymorphism and residual urine. Calcium level was the predictor factor for QT dispersion. The ACE genotype correlated with QT dispersion, corrected QT dispersion, hemoglobin, and residual urine, and inversely correlated with serum potassium. Corrected QT dispersion correlated with ACE gene polymorphism and residual urine. The DD genotype of ACE had significally greater QT dispersion and corrected QT dispersion than the II and ID genotypes. Conclusions. Our study showed that the most important parameter affecting corrected QT dispersion was ACE gene polymorphism on the background of D allelle. Patients carrying this allelle need special attention regarding optimal suppression of renin-angiotensin-aldosteron system activity.en_US
dc.identifier.endpage222en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue3en_US
dc.identifier.pmid28575882en_US
dc.identifier.scopus2-s2.0-85020472968en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9242
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000403773600006
dc.identifier.volume11en_US
dc.identifier.wosWOS:000403773600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTekçe, Hikmet
dc.language.isoenen_US
dc.publisherIranian Soc Nephrolgyen_US
dc.relation.ispartofIranian Journal Of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Kidney Failureen_US
dc.subjectQT Dispersionen_US
dc.subjectGene Polymorphismen_US
dc.subjectAngiotensin-Converting Enzymeen_US
dc.subjectVentricular Arrhythmiasen_US
dc.titleRelationship between angiotensin-converting enzyme gene polymorphism and QT dispersion in hemodialysis patientsen_US
dc.typeArticleen_US

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