Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?

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dc.authorid0000-0001-6013-7330en_US
dc.authorid0000-0002-2271-3242
dc.contributor.authorYaşar, Zehra
dc.contributor.authorKıraklı, Cenk
dc.contributor.authorÇimen, Pınar
dc.contributor.authorUçar, Zeynep Zeren
dc.contributor.authorTalay, Fahrettin
dc.date.accessioned2021-06-23T19:42:30Z
dc.date.available2021-06-23T19:42:30Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Non-thyroidal illness syndrome (NTIS) is considered to be associated with adverse outcomes in intensive care unit (ICU) patients. In this study, we evaluated the association between NTIS and prolonged weaning in chronic obstructive pulmonary disease (COPD) patients admitted to the ICU. Materials and methods: In total, 125 patients with COPD admitted to our ICU who underwent invasive mechanical ventilation (MV) were enrolled. We collected each patient's baseline characteristics including Acute Physiology and Chronic Health Evaluation (APACHE) II score, body mass index (BMI), and thyroid hormones 24 h after ICU admission. The presence of pulmonary infection was also recorded. The primary outcome was prolonged weaning, defined as patients who failed at least three weaning attempts or required > 7 days of weaning after the first spontaneous breathing trial. Results: Of the 127 patients studied, 64 had normal thyroid function tests and 61 had NTIS. Patients with NTIS had significantly higher APACHE II scores, prolonged weaning, and pulmonary infection. Patients with NTIS had a higher risk for prolonged weaning (odds ratio, OR = 3.21; 95% CI = 1.31-7.83). The presence of pulmonary infection was also an independent risk factors for prolonged weaning. Conclusions: NTIS may be an independent predictor for prolonged weaning in intubated COPD patients.en_US
dc.identifier.endpage10121en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.pmid26309710en_US
dc.identifier.scopus2-s2.0-84938341329en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage10114en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8515
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000359295600232
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538104/
dc.identifier.volume8en_US
dc.identifier.wosWOS:000359295600232en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYaşar, Zehra
dc.institutionauthorTalay, Fahrettin
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNTISen_US
dc.subjectProlonged Weaningen_US
dc.subjectICUen_US
dc.subjectCOPDen_US
dc.titleIs non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?en_US
dc.typeArticleen_US

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