Does mean platelet volume decrease in the presence of coronary artery fistula?

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dc.authorid0000-0002-4585-3707en_US
dc.authorid0000-0002-1495-1697en_US
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-6965-7444
dc.authorid0000-0003-2399-9585
dc.authorid0000-0003-3817-851X
dc.authorid0000-0003-1784-3584
dc.contributor.authorSincer, İsa
dc.contributor.authorÇekici, Yusuf
dc.contributor.authorCoşgun, Mehmet
dc.contributor.authorAktaş, Gülali
dc.contributor.authorGüneş, Yılmaz
dc.contributor.authorErdal, Emrah
dc.contributor.authorMansıroğlu, Aslı Kurtar
dc.contributor.authorİnanır, Mehmet
dc.date.accessioned2021-06-23T19:51:21Z
dc.date.available2021-06-23T19:51:21Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Coronary artery fistula (CAF) is an abnormal connection that links a coronary artery to a cardiac chamber or another major blood vessel. Several studies have shown the association between mean platelet volume (MPV) and cardiovascular diseases. In the literature, there is no previous study about the association between hematologic parameters and congenital CAF. For this reason, we aimed to investigate the association of MPV with CAF. Methods: 70 patients with normal coronary arteries and 50 with coronary artery fistulas were included. Routine blood and biochemical parameters were measured before the arteriography. Differences between groups for continuous variables were analyzed with t- test or Mann-Whitney test. P values < 0.05 were considered significant. Regression analysis was used to find independent predictors of CAF. Results: Baseline patient demographics, including age and clinical risk factors, were similar between the groups. Compared to the control group, median (IQR) High-density lipoprotein cholesterol (HDL) levels were significantly higher (p=0.04) and MPV levels were significantly lower in the CAF group (8.84 +/- 1.71fL vs. 10.43 +/- 1.34, p < 0.001). In the multivariate analysis, only MPV was a significant predictor of CAF (p < 0.001, 95% CI for OR: 0.438 (0.306-0.629). A negative correlation was found between MPV and fistulae in Pearson's correlation test (r: -0.454, p < 0.001). An MPV level of < 9,6 fL showed sensitivity, specificity, positive predictive value and negative predictive value of 80%, 68%, 71% and 78% respectively (AUC = 0.766, 95% CI, 0.678-0.854) for the prediction of CAF. Conclusion: The present study suggests that MPV may decrease in patients with CAF.en_US
dc.identifier.doi10.5935/abc.20190088
dc.identifier.endpage75en_US
dc.identifier.issn0066-782X
dc.identifier.issue1en_US
dc.identifier.pmid31271594en_US
dc.identifier.scopus2-s2.0-85071350724en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://doi.org/10.5935/abc.20190088
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9971
dc.identifier.volume113en_US
dc.identifier.wosWOS:000480360200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSincer, İsa
dc.institutionauthorAktaş, Gülali
dc.institutionauthorCoşgun, Mehmet
dc.institutionauthorGüneş, Yılmaz
dc.institutionauthorMansıroğlu, Aslı Kurtar
dc.institutionauthorCoşgun, Mehmet
dc.language.isoenen_US
dc.publisherArquivos Brasileiros Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros De Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArteriovenous Fistulaen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectAngiographyen_US
dc.subjectEndothelium/Dysfunctionen_US
dc.titleDoes mean platelet volume decrease in the presence of coronary artery fistula?en_US
dc.typeArticleen_US

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