Which patients with advanced cancer and biliary obstruction benefit from biliary stenting most? An analysis of prognostic factors

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dc.authorid0000-0002-2572-0376
dc.contributor.authorAbalı, Hüseyin
dc.contributor.authorSezer, Ahmet
dc.contributor.authorOğuzkurt, Levent
dc.contributor.authorGürel, Kamil
dc.contributor.authorÖzkan, Uğur
dc.date.accessioned2021-06-23T19:34:42Z
dc.date.available2021-06-23T19:34:42Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPatients with advanced cancer may present with obstructive jaundice. Biliary stenting is the treatment of choice. However, which patients benefit most is not well-defined, yet. Our aim was to delineate the clinical factors affecting prognosis. Charts of 140 patients with advanced cancer who underwent biliary stenting were retrospectively analyzed. Their median age was 63.5 years. Of these patients, 73 (52.1 %) were male, 32 (22.9 %) had ECOG PS 1 and 81 (57.9 %) had PS 2. The most frequent cancer types were cholangiocellular cancer (64, 45.7 %) and pancreatic cancer (36, 25.7 %). Median overall survival (OS) was 141 (95 % CI, 100.7-185.3) days. Female patients lived longer (161.0 vs. 124.0 days) (p = 0.036). Those patients with colorectal cancer lived the longest (667.0 days), followed by cholangiocellular (211.0 days), and gastric cancers (106.0 days) (p = 0.004). The distribution of primary diagnosis differed significantly between sexes: cholangiocellular cancer was present in 22 (30.1 %) out of 73 men and 42(62.7 %) out of 67 women (chi-square p < 0.001). There was a trend for longer overall survival if ALT (p = 0.08) and AST (p = 0.06) were normalized after stent insertion. Of the 137 patients, 63 (45.5 %) did not experience any complication. In 74 patients with complications, there were 39 (28.5 %) episodes of cholangitic infections and 35 (25.5 %) biliary obstructions. In three patients, we could not find data on infections. Underlying malignancy, hence the natural biology and the therapeutic expectations are probably the most important factors which must be considered during decision-making.en_US
dc.identifier.doi10.1007/s00520-012-1636-z
dc.identifier.endpage1135en_US
dc.identifier.issn0941-4355
dc.identifier.issue4en_US
dc.identifier.pmid23132146en_US
dc.identifier.startpage1131en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-012-1636-z
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7599
dc.identifier.volume21en_US
dc.identifier.wosWOS:000315444600027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürel, Kamil
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive Jaundiceen_US
dc.subjectBiliary Stenten_US
dc.subjectCanceren_US
dc.titleWhich patients with advanced cancer and biliary obstruction benefit from biliary stenting most? An analysis of prognostic factorsen_US
dc.typeArticleen_US

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