Comparison of the Effect of Different Treatment Doses of Intrastromal Vancomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus Aureus (MRSA) Keratitis

Basit Öğe Kaydı
dc.authorid/0000-0001-5454-3113
dc.contributor.authorBayrak, Abdullah
dc.contributor.authorCelebi, Serdal
dc.contributor.authorAvcioglu, Fatma
dc.contributor.authorAlkan, Yunus
dc.date.accessioned2024-09-25T19:57:30Z
dc.date.available2024-09-25T19:57:30Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractPurposeTo compare the effect of different doses of vancomycin on a rabbit model of MRSA keratitis.MethodsTwenty-four eyes of 24 New-Zealand White rabbits were included in the study. MRSA keratitis was applied to 24 left eyes of 24 New Zealand rabbits. Twenty-four hours after MRSA inoculation; 0.5 mg/0.1 mL, 1 mg/0.1 mL, and 2 mg/0.1 mL and balanced salt solution were administered to 6 rabbits in 4 groups, respectively.ResultsThe effect of different doses of vancomycin on reducing bacterial load was found to be statistically significant when each was compared to the control group (p = 0.006). When comparing the dosages with each other, no superiority was shown (p = 0.297, p = 0.749, p = 0.262 respectively). There was a significant increase in the posttreatment total clinical score in the control and 2 mg/0.1 mL groups compared to the pretreatment score (p = 0.001, p = 0.001 respectively).ConclusionIt is emphasized that necessary treatment can be achieved by administering less antibiotic (0.5 mg/0.1 mL) to the corneal intrastromal area.en_US
dc.identifier.doi10.1080/09273948.2024.2382928
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.pmid39115284en_US
dc.identifier.scopus2-s2.0-85200897459en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1080/09273948.2024.2382928
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13458
dc.identifier.wosWOS:001286797200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofOcular Immunology And Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCorneal intrastromal therapyen_US
dc.subjectfortified topical dropen_US
dc.subjectkeratitisen_US
dc.subjectMethicillin-resistant Staphylococcus aureus(MRSA)en_US
dc.subjectvancomycinen_US
dc.titleComparison of the Effect of Different Treatment Doses of Intrastromal Vancomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus Aureus (MRSA) Keratitisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu