Molecularly imprinted based surface plasmon resonance nanosensors for microalbumin detection

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dc.authorid0000-0003-2245-8074en_US
dc.authorid0000-0003-3260-1639
dc.contributor.authorEsentürk, Meltem Koca
dc.contributor.authorAkgönüllü, Semra
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2021-06-23T19:51:41Z
dc.date.available2021-06-23T19:51:41Z
dc.date.issued2019
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya Ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractHuman serum albumin (HSA) is a major blood plasma protein also found in urine where its existence may be a marker of some types of liver or kidney dysfunction. Herein, we fabricated a novel surface plasmon resonance (SPR) nanosensor for selective, sensitive, and label-free microalbumin detection both in aqueous and urine sample solutions. First, HSA-imprinted nanoparticles were synthesized, which consist of ethylene glycol dimethacrylate and N-methacryloyl-L-leucine methyl ester as a cross-linker and functional monomer. The nanoparticles were characterized by zeta-size and scanning electron microscope analyses and were dropped onto the SPR chip surface to make HSA sensitive nanosensor. Characterization studies of HSA-imprinted SPR chip were carried out by atomic force microscopy, Fourier-transform infrared spectroscopy, contact angle, and ellipsometer. The limit of detection and limit of quantification values of HSA-imprinted SPR nanosensor were calculated as 0.7pM and 1.9pM for the concentration range of 0.15-500nM. Selectivity studies of HSA-imprinted SPR nanosensor were achieved with hemoglobin and transferrin proteins which were chosen as competitor molecules. HSA-imprinted SPR nanosensor was displayed highly selective and sensitive to HSA.en_US
dc.identifier.doi10.1080/09205063.2019.1600181
dc.identifier.endpage661en_US
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue8en_US
dc.identifier.pmid30920349en_US
dc.identifier.scopus2-s2.0-85063972206en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage646en_US
dc.identifier.urihttps://doi.org/10.1080/09205063.2019.1600181
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10029
dc.identifier.volume30en_US
dc.identifier.wosWOS:000467749600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Biomaterials Science-Polymer Editionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicroalbumin Detectionen_US
dc.subjectNanoparticlesen_US
dc.subjectSurface Plasmon Resonanceen_US
dc.subjectNanosensoren_US
dc.titleMolecularly imprinted based surface plasmon resonance nanosensors for microalbumin detectionen_US
dc.typeArticleen_US

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