Effects of fisetin on ethanol-induced rewarding properties in mice

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dc.authoridYalniz, Yasin/0000-0003-1587-7369
dc.authoridBerkoz, Mehmet/0000-0003-4219-8054
dc.authoridDemirel, Mustafa Enes/0000-0001-5187-5737
dc.authoridYunusoglu, Oruc/0000-0003-1075-9574
dc.contributor.authorYalniz, Yasin
dc.contributor.authorYunusoglu, Oruc
dc.contributor.authorBerkoz, Mehmet
dc.contributor.authorDemirel, Mustafa Enes
dc.date.accessioned2024-09-25T19:57:49Z
dc.date.available2024-09-25T19:57:49Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Alcohol use disorder (AUD) is a chronic relapsing disorder associated with compulsive drinking of alcohol. Natural flavonoid fisetin affects a variety of transmitter systems relevant to AUD, such as aminobutyric acid, N-methyl-D-aspartate, and dopamine, as well as peroxisome proliferator-activated receptors.Objectives: This study investigated fisetin's impact on the motivational properties of ethanol using conditioned place preference (CPP) in mice (n = 50). Methods: Mice were conditioned with ethanol (2 g/kg, i.p.) or saline on alternating days for 8 consecutive days and were given intragastric (i.g.) fisetin (10, 20, or 30 mg/kg, i.g.), 45 min before ethanol conditioning. During extinction, physiological saline was injected to the control and ethanol groups, and fisetin was administered to the fisetin groups. To evaluate the effect of fisetin on the reinstatement of ethanol-induced CPP, fisetin was given 45 min before a priming dose of ethanol (0.4 g/kg, i.p.; reinstatement test day). Results: Fisetin decreased the acquisition of ethanol-induced CPP (30 mg/kg, p < .05) and accelerated extinction (20 and 30 mg/kg, p < .05). Furthermore, fisetin attenuated reinstatement of ethanol-induced CPP (30 mg/kg, p < .05). Conclusions: Fisetin appears to diminish the rewarding properties of ethanol, as indicated by its inhibitory effect and facilitation of extinction in ethanol-induced CPP. These findings imply a potential therapeutic application of fisetin in preventing ethanol-seeking behavior, promoting extinction, and reducing the risk of relapse.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [1919B012202512]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific and Technological Research Council of Turkey (TUBITAK) [grant number: 1919B012202512].en_US
dc.identifier.doi10.1080/00952990.2023.2292976
dc.identifier.endpage83en_US
dc.identifier.issn0095-2990
dc.identifier.issn1097-9891
dc.identifier.issue1en_US
dc.identifier.pmid38235981en_US
dc.identifier.scopus2-s2.0-85182450230en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1080/00952990.2023.2292976
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13616
dc.identifier.volume50en_US
dc.identifier.wosWOS:001145408900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofAmerican Journal of Drug And Alcohol Abuseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectFisetinen_US
dc.subjectalcoholen_US
dc.subjectconditioned place preferenceen_US
dc.subjectrewarden_US
dc.subjectmiceen_US
dc.titleEffects of fisetin on ethanol-induced rewarding properties in miceen_US
dc.typeArticleen_US

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