Nötrofil/lenfosit oranının koroner ektazisi varlığı ve yaygınlığı ile ilişkisi
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Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Nötrofil/lenfosit oranının (N/L oranı) kardiyovasküler olay ve mortalite ile ilişkili olduğu çalışmalarda gösterilmiştir. Bu çalışmada, koroner arter ektazisi (KAE) olan hastalarda N/L oranı araştırıldı. Çalışma planı: Koroner anjiyografi sonrası KAE tanısı konu- lan 50 hasta (29 erkek, 21 kadın; ortalama yaş 51.1±7.1 yıl) ve normal koroner arter saptanan 28 hasta (16 erkek, 12 ka- dın; ortalama yaş 49.5±9.4 yıl) çalışmaya dahil edildi. Temel demografik ve klinik özellikler kaydedildi. Ektazik segment sayısı hesaplandı. Hematolojik parametreler ölçüldü ve N/L oranı hesaplandı. Bulgular: Nötrofil/lenfosit oranı KAE grubunda anlamlı olarak yüksekti (sırasıyla, ortanca [%25-%75 persantil] 2.2 [1.6-3.0] ve 1.8 [1.4-2.0]; p=0.014). Spearman korelasyon analizinde N/L oranının ektazik segment sayısıyla pozitif korelasyon gösterdiği saptandı (r=0.35; p<0.002). Çok değişkenli lojistik regresyon analizi ile de KAE ve N/L oranı arasındaki bağımsız ilişki gösterildi (odds oranı 2.674, %95 güven aralığı 1.184- 6.039, p=0.018). Sonuç: Koroner ektazili hastalarda N/L oranı artmıştır. N/L oranı KAE varlığı ve ciddiyetiyle ilişkilidir.
Objectives: It has been shown that the neutrophil to lymphocyte ratio (N/L ratio) is associated with cardiovascular events and mortality. In this study, we investigated the N/L ratio in patients with coronary artery ectasia (CAE). Study design: Fifty patients (29 men, 21 women; mean age, 51.1±7.1 years) diagnosed as CAE using coronary angiography were included in the study. The control group consisted of 28 patients (16 men, 12 women; mean age, 49.5±9.4 years) who had normal coronary arteries as determined by coronary angiography. Baseline characteristics were recorded. The number of ectatic segments was noted. Hematologic parameters were measured and the N/L ratio was calculated. Results: The N/L ratio was significantly higher in the CAE group compared with the control group (median [25-75% percentile] 2.2 [1.6-3.0] vs. 1.8 [1.4-2.0], p=0.014, respectively). The Spearman correlation analysis demonstrated that the N/L ratio positively correlated with the number of ectatic segments (r=0.35; p<0.002). Multivariate logistic regression analysis showed an independent relationship between CAE and the N/L ratio (odds ratio 2.674, 95% confidence interval 1.184-6.039, p=0.018). Conclusion: The N/L ratio is higher in patients with CAE. This ratio is related to presence and severity of CAE.
Objectives: It has been shown that the neutrophil to lymphocyte ratio (N/L ratio) is associated with cardiovascular events and mortality. In this study, we investigated the N/L ratio in patients with coronary artery ectasia (CAE). Study design: Fifty patients (29 men, 21 women; mean age, 51.1±7.1 years) diagnosed as CAE using coronary angiography were included in the study. The control group consisted of 28 patients (16 men, 12 women; mean age, 49.5±9.4 years) who had normal coronary arteries as determined by coronary angiography. Baseline characteristics were recorded. The number of ectatic segments was noted. Hematologic parameters were measured and the N/L ratio was calculated. Results: The N/L ratio was significantly higher in the CAE group compared with the control group (median [25-75% percentile] 2.2 [1.6-3.0] vs. 1.8 [1.4-2.0], p=0.014, respectively). The Spearman correlation analysis demonstrated that the N/L ratio positively correlated with the number of ectatic segments (r=0.35; p<0.002). Multivariate logistic regression analysis showed an independent relationship between CAE and the N/L ratio (odds ratio 2.674, 95% confidence interval 1.184-6.039, p=0.018). Conclusion: The N/L ratio is higher in patients with CAE. This ratio is related to presence and severity of CAE.
Açıklama
Anahtar Kelimeler
Koroner Ektazili Hastalar, Coronary Artery Ectasia
Kaynak
Türk Kardiyoloji Derneği Arşivi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
41
Sayı
3
