General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors

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dc.authorid0000-0002-5293-7837
dc.contributor.authorCanöz, Özlem M.
dc.contributor.authorBelenli, Olcay Kandemir
dc.contributor.authorPatıroǧlu, Tahir Ercan
dc.date.accessioned2021-06-23T18:54:51Z
dc.date.available2021-06-23T18:54:51Z
dc.date.issued2002
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractDuring the period of 1996-1998 ninety-four gastrectomy specimens with gastric carcinoma referred to Erciyes University, Medical Faculty, Department of Pathology, were examined histopathologically, histochemically and immunohistochemically. General characteristics of gastric carcinomas and prognostic factors were studied. According the Lauren classification, of the 94 cases of gastric carcinomas, 56 were intestinal type, 21 were diffuse type and 17 were mixed type carcinoma. The association rates of Helicobacter pylori, chronic atrophic gastritis and intestinal metaplasia with gastric carcinomas were high. There was strong immunorectivity with HSP70 in 62,5% of the intestinal type carcinomas. This ratios were lower in diffuse and mixed type carcinomas (p<0.05). The more tumor size and invision depth increased, the more HSP70 immunoreactivity was obtained (p<0.05). HSP70 immunorectivity was considerably higher in the patients having lymph node metastasis and vascular invasion (p<0.05). It was found that the NK cell number was low in the tumor but higher around the tumor in early gastric carcinomas, compared with advanced carcinomas (p>0.05). In the tumors larger than 10 cm with vascular invasion, NK cell number was lower around the tumor (p>0.05). Defining prognostic factors of gastric carcinomas is of importance to clinicians. It is thought that HSP70 immunoreactivity, besides invasion depth, lymph node metastasis, vascular invasion, tumor size and inflammatory reaction against the tumor, is important in prognosis and associated with advanced stage.en_US
dc.identifier.doi10.1007/BF03036742
dc.identifier.endpage269en_US
dc.identifier.issn1219-4956
dc.identifier.issue4en_US
dc.identifier.pmid12579213en_US
dc.identifier.scopus2-s2.0-0037001673en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.1007/BF03036742
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4596
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBelenli, Olcay Kandemir
dc.language.isoenen_US
dc.relation.ispartofPathology and Oncology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric Carcinomaen_US
dc.subjectHSP70en_US
dc.subjectNK-cellen_US
dc.subjectPrognostic Factorsen_US
dc.titleGeneral features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factorsen_US
dc.typeArticleen_US

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