Dynamic thiol-disulfide homeostasis as an oxidative stress marker in ankylosing and undifferentiated

Basit Öğe Kaydı
dc.authoridDogan, Ismail/0000-0002-7603-9484
dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.contributor.authorOzturk, Cemaleddin
dc.contributor.authorErten, Sukran
dc.contributor.authorAlisik, Murat
dc.contributor.authorDogan, Ismail
dc.contributor.authorUstuner, Guniz Yanik
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-09-25T19:56:20Z
dc.date.available2024-09-25T19:56:20Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground/aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-disulfide levels as a marker of oxidative stress between SpA patients and healthy controls.Materials and methods: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and disulfide (D) levels were measured using the fully automated Erel method. The ratios NT/TT, D/TT, and D/NT were calculated. Thiol-disulfide levels were compared between the SpA groups and the healthy controls.Results: The NT and NT/TT ratios were found to be significantly lower in the SpA group (p < 0.001). The disulfide, D/NT, and D/TT ratios were found to be significantly higher in the SpA group (p < 0.001). In pairwise comparisons between the SpA subgroups, the NT and TT levels were lower in the USpA group than in the AS group (p = 0.021), but serum disulfide levels were higher in the USpA group than in the AS group (p = 0.004). Among the patients with SpA, the group taking antitumor necrosis factor (anti-TNF) had lower TT measurements compared to the group taking conventional disease modifying antirheumatic drugs (DMARD) (p = 0.039).Conclusion: The thiol-disulfide balance is disturbed in favor of disulfide in SpA patients compared to healthy volunteers. Native and total thiol measurements correlate with acute phase reactants and might be used to monitor disease activity. Anti-TNF therapy might control the oxidative degenerative process better than the conventional DMARD in SpA patients.en_US
dc.identifier.doi10.55730/1300-0144.5705
dc.identifier.endpage1394en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid38813044en_US
dc.identifier.scopus2-s2.0-85175531518en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1387en_US
dc.identifier.trdizinid1209086en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5705
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1209086
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13233
dc.identifier.volume53en_US
dc.identifier.wosWOS:001108669900046en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectspondyloarthropathyen_US
dc.subjectthiolen_US
dc.subjectdisulfideen_US
dc.subjectoxidative stressen_US
dc.subjecttumor necrosis factor-a antagonisten_US
dc.titleDynamic thiol-disulfide homeostasis as an oxidative stress marker in ankylosing and undifferentiateden_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu