Thiol-disulphide homeostasis in patients with general anxiety disorder and panic disorder
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The aim of this study was to evaluate the dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in newly diagnosed and medication-naive general anxiety disorder (GAD) and panic disorder (PD) patients. Method: Medication-naive patients with GAD (n=21) or PD (n=23) and healthy individuals (n=23) were enrolled. Patients were administered a sociodemographic form, Beck Depression Inventory, and Beck Anxiety Inventory. Routine biochemical parameters, native thiol, total thiol, and disulphide parameters were measured in all patients and healthy individuals. Results: The native thiol levels of the GAD and PD groups were found significantly lower than those of the control group (p<0.001 and p=0.03, respectively), whereas the disulphide levels and disulphide/native thiol ratios of both patient groups were significantly higher than that of the control group (p<0.001 and p=0.011, respectively). There was no statistically significant difference between the GAD and PD groups with regard to thiol and disulphide levels. Conclusion: Oxidative stress is considered to be one of the molecular changes underlying the pathogenesis of GAD and PD. This study showed that dynamic thiol-disulphide homeostasis was disturbed due to an increase in oxidants and a decrease in antioxidants in GAD and PD patients, suggesting that antioxidant replacement interventions might be an option in the treatment of these disorders.
Açıklama
Anahtar Kelimeler
Generalized Anxiety Disorder, Panic Disorder, Thiol-disulphide Homeostasis
Kaynak
Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
32
Sayı
4
