Can serum lipid and CRP levels predict the "severity" of aortic valve stenosis?

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dc.authorid0000-0003-2541-4675
dc.authorid0000-0002-2262-3087
dc.authorid0000-0003-2005-0737
dc.authorid0000-0002-8877-3520
dc.authorid0000-0002-6482-9913
dc.contributor.authorGündüz, Hüseyin
dc.contributor.authorAkdemir, Ramazan
dc.contributor.authorBinak, Emrah
dc.contributor.authorTamer, Ali
dc.contributor.authorKeser, Nurgül
dc.contributor.authorUyan, Cihangir
dc.date.accessioned2021-06-23T19:17:34Z
dc.date.available2021-06-23T19:17:34Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground - Results of the studies performed have suggested that hypercholesterolaemia and inflammation are important aetiologic factors in aortic valve stenosis (AVS). However up to now no such data has been obtained to evaluate whether these predictors may still serve as valuable tools to estimate the progression and severity of AVS. If factors contributing to the "progression" of degenerative process can be understood and preventive measures can be taken, both clinical and economical beneficial effects can be achieved. The objective of this study is to investigate the correlation of serum cholesterol, triglyceride and CRP levels with the severity of aortic stenosis echocardiographically evaluated in patients with aortic valve stenosis. Material and methods -Aortic valvular areas of 60 patients (pts) hospitalized in our clinic with suspected AVS were calculated with Doppler echocardiography. Patients were grouped into mild, moderate and advanced AVS, each category containing 20 pts, and then were subclassified regarding those with and without coronary artery disease(CAD). Results -Total cholesterol and CRP levels were found to be 215 +/- 42 mg/dl and 2.0 +/- 1.4 mg/dl; 224 +/- 43 mg/dl and 2.4 +/- 2.1 mg/dl; 225 +/- 55 mg/dl and 2.7 +/- 2.1 mg/dl in pts with mild, moderate and advanced AVS, respectively. A statistically significant difference was not detected among the three groups (p>0.05). When subclasses were classified the levels were found to be much more increased in those patients having additional CAD. Conclusion - We have demonstrated that severity of AVS does not correlate significantly with hypercholesterolaemia and CRP and their levels do not rise in accordance with increasing severity of AVS. Elevations of lipid levels in AVS were found to correlate with the presence of CAD rather than the severity of AVS. So, not in patients with simply AVS but in patients under higher cardiovascular risks, investigation of CRP plus lipid levels might provide benefit with respect to preventive treatment and benefit from cholesterol-lowering drugs can be expected in such kind of patients.en_US
dc.identifier.doi10.2143/AC.58.4.2005289
dc.identifier.endpage326en_US
dc.identifier.issn0001-5385
dc.identifier.issue4en_US
dc.identifier.pmid12948037en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.2143/AC.58.4.2005289
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5466
dc.identifier.volume58en_US
dc.identifier.wosWOS:000184772100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGündüz, Hüseyin
dc.institutionauthorUyan, Cihangir
dc.institutionauthorTamer, Ali
dc.institutionauthorAkdemir, Ramazan
dc.institutionauthorGündüz, Hüseyin
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAortic Stenosisen_US
dc.subjectHyperlipidaemiaen_US
dc.subjectCRPen_US
dc.titleCan serum lipid and CRP levels predict the "severity" of aortic valve stenosis?en_US
dc.typeArticleen_US

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