Improvement of antibacterial and biocompatibility properties of electrospray biopolymer films by ZnO and MCM-41

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dc.authorid0000-0003-1956-4474en_US
dc.authorid0000-0001-7712-2813
dc.authorid0000-0003-2933-5296
dc.authorid0000-0002-8212-7149
dc.contributor.authorMutlu, Esra Cansever
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorYıldırım, Muhammet
dc.contributor.authorFicai, Anton
dc.contributor.authorFicai, Denisa
dc.contributor.authorOktar, Faik Nüzhet
dc.contributor.authorTitu, Mihail
dc.contributor.authorÇetinkaya, Ayhan
dc.date.accessioned2021-06-23T19:54:07Z
dc.date.available2021-06-23T19:54:07Z
dc.date.issued2020
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.description.abstractThis study aims the improvement of antibacterial and biocompatibility properties of electrospray ternary blends of chitosan/poly(ethylene glycol)/hyaluronic acid. It conserves microscale particle structure even after incorporating zinc oxide (ZnO), the zeolite Mobil Composition of Matter No. 41 (MCM41) and penicillin G during this technique. Three different electrospray (ESP) blend compositions (ESPI, ESPII and ESPIII) have been produced in order to improve both antibacterial activity against to bothgram-positive and gram-negativebacteria and biocompatibility. Results of FTIR spectroscopy and microscopy verified with SEM, EDS and AFM analyses. Hyaluronic acid surface has been specified definitely through ZnO-based ESPI surface composed of heterogeneously dispersed microparticles. Surface structures of ESPII and ESPIII have more homogenously dispersed microparticles as hill-valley surface by the aid of MCM 41-PEN. Antibacterial activity has been performed by Kirby-Bauer method. ESPI has good antibacterial activity against both gram-positive (S. aureusandS. epidermidis) and gram-negative bacteria (E. cloacea). Each electrospray film displayed good biocompatibility against to mouse fibroblast cell line L929 (ATTC number CCL-1). The highest amount of cell proliferation has been detected on ESPIII surface.en_US
dc.identifier.doi10.1007/s00289-019-02937-2
dc.identifier.endpage3675en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85072117150en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3657en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-019-02937-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10426
dc.identifier.volume77en_US
dc.identifier.wosWOS:000540604000018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYıldırım, Arzu Birinci
dc.institutionauthorYıldırım, Muhammet
dc.institutionauthorÇetinkaya, Ayhan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrosprayen_US
dc.subjectHAen_US
dc.subjectZnOen_US
dc.subjectMCM 41en_US
dc.subjectMicroparticlesen_US
dc.titleImprovement of antibacterial and biocompatibility properties of electrospray biopolymer films by ZnO and MCM-41en_US
dc.typeArticleen_US

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