A surface plasmon resonance sensor with synthetic receptors decorated on graphene oxide for selective detection of benzylpenicillin

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dc.authorid0000-0001-5173-1522en_US
dc.authorid0000-0001-7292-7241en_US
dc.authorid0000-0003-3260-1639en_US
dc.contributor.authorÇelik, Onur
dc.contributor.authorSaylan, Yeşeren
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-02-06T07:38:00Z
dc.date.available2024-02-06T07:38:00Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractAntibiotic residues in foods, water and the environment reveal antibiotic-resistant bacterial strains, disrupting the ecological balance and causing serious health problems. For these reasons, the detection of antibiotic residues is crucial for the protection of human health. Herein, the detection of benzylpenicillin antibiotic from aqueous and milk sample solutions was carried out by surface plasmon resonance (SPR) sensor using synthetic receptor -molecularly imprinted polymer. The benzylpenicillin-imprinted poly(hydroxyethyl methacrylate-graphene oxide-N-methacryloyl-L-phenylalanine) (MIP-GO) SPR sensor was prepared. Benzylpenicillin detection was performed by MIP-GO SPR sensor in a 1-100 ppb concentration range of benzylpenicillin with 0.9665 linear correlation and 0.021 ppb detection limit. Selectivity analysis showed that the MIP-GO SPR sensor detected the benzylpenicillin molecule 8.16 times more selectively than amoxicillin and 14.04 times more selectively than ampicillin. To examine the imprinting efficiency, non-imprinted poly(hydroxyethyl methacrylate-graphene oxide-N-methacryloyl-L-phenylalanine) (NIP-GO) SPR sensor was also prepared using the same procedure without benzylpenicillin addition. Since graphene oxide (GO) was added to enhance the sensor signal response by increasing sensitivity, the control analyses were performed by a poly(hydroxyethyl methacrylate-N-meth-acryloyl-L-phenylalanine) (MIP) SPR sensor without adding GO. Moreover, repeatability studies of MIP-GO SPR sensor were statistically evaluated and the RSD of intra-day assays less than 1% specified that there was no loss of performance for the benzylpenicillin detection ability even after four cycles. As a real food sample analysis, the benzylpenicillin spiked and unspiked milk samples were evaluated and high-performance liquid chromatography experiments were carried out for validation.en_US
dc.identifier.citationÇelik, O., Saylan, Y., Göktürk, I., Yılmaz, F., & Denizli, A. (2023). A surface plasmon resonance sensor with synthetic receptors decorated on graphene oxide for selective detection of benzylpenicillin. Talanta, 253, 123939.en_US
dc.identifier.doi10.1016/j.talanta.2022.123939
dc.identifier.endpage8en_US
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.pmid36152604en_US
dc.identifier.scopus2-s2.0-85138137097en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.talanta.2022.123939
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11980
dc.identifier.volume253en_US
dc.identifier.wosWOS:000862168200007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTalantaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzylpenicillin Detectionen_US
dc.subjectGraphene Oxideen_US
dc.subjectMolecular Imprintingen_US
dc.subjectSurface Plasmon Resonance Sensoren_US
dc.subjectBeta-Lactam Antibioticsen_US
dc.subjectPenicillin-Gen_US
dc.titleA surface plasmon resonance sensor with synthetic receptors decorated on graphene oxide for selective detection of benzylpenicillinen_US
dc.typeArticleen_US

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