Virulence factors of Pseudomonas aeruginosa strains isolated from clinical samples and role of quorum sensing signal molecules in the pathogenesis of the disease

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dc.authorid0000-0003-0980-2205
dc.authorid0000-0002-8637-6345
dc.contributor.authorÖnal, Süleyman
dc.contributor.authorArıdoğan, Buket Cicioğlu
dc.contributor.authorGönen, İbak
dc.contributor.authorTaş, Tekin
dc.contributor.authorKaya, Selçuk
dc.date.accessioned2021-06-23T19:42:31Z
dc.date.available2021-06-23T19:42:31Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Pathogenicity of Pseudomonas aeruginosa depends on multiple cell-associated factors and virulence factors including "Quorum sensing (QS)" molecules. QS system enables the bacterium to determine the population density around it and the bacterium uses this data to control the regulation of many of its genes. The aim of this study was to determine whether there was QS insufficient subspecies infective for humans, and to identify the relations between specific infection types and virulence factors. Materials and methods: A hundred P. aeruginosa strains isolated from different clinical specimens were used in our study. Quantitative measurements of elastase, alkaline protease, pyocyanin, and biofilm formation were done. Strains were investigated to produce long and short chain signal molecules taken part in QS system. Results: Elastase activities of the subspecies isolated from sputum and blood specimens were detected higher than those from other localizations. Pyocyanin values of the urine specimens were detected higher than those of blood, wound and sputum isolates. Biofilm formation level of the urinary isolates was significantly higher than the other isolates. All the subspecies produced long chain signal molecule, whereas 29 isolates produced short chain signal molecule. Productions of elastase, alkaline protease and pyocyanin in the short chain signal molecule producing strains were higher than those cannot produce. Conclusion: These results suggested that the Quorum sensing could make the strains much virulent, and could play an important role in pathogenicity. To date, the QS system has not been clearly identified yet for many microorganisms, however, the agents targeting the QS system may be therapeutic alternatives in the treatment and prophylaxis of infections in the future.en_US
dc.identifier.endpage855en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84944279242en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage851en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8519
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000357346000014
dc.identifier.volume31en_US
dc.identifier.wosWOS:000357346000014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTaş, Tekin
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPseudomonas Aeruginosaen_US
dc.subjectQuorum Sensingen_US
dc.subjectPathogenicityen_US
dc.subjectVirulence Factorsen_US
dc.titleVirulence factors of Pseudomonas aeruginosa strains isolated from clinical samples and role of quorum sensing signal molecules in the pathogenesis of the diseaseen_US
dc.typeArticleen_US

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