Comparison of fusidic acid susceptibility of staphylococci: A multicenter study

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dc.authorid0000-0001-9678-0862
dc.authorid0000-0001-5121-3100
dc.contributor.authorÇetinkol, Yeliz
dc.contributor.authorAladal, Murat
dc.contributor.authorÜnal, Nevzat
dc.contributor.authorBayramoğlu, Gülçin
dc.contributor.authorAhmetbayık, Seyit
dc.contributor.authorDoğan, Metin
dc.contributor.authorDurmaz, Süleyman
dc.date.accessioned2024-09-25T20:00:08Z
dc.date.available2024-09-25T20:00:08Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü en_US
dc.description.abstractIntroduction: The increasing antibiotic resistance of staphylococci, an important factor among societal and hospital-sourced infection factors, reduces the treatment choices available. Fusidic acid (FA), the use of which has recently come to the agenda again, is thought to form a new alternative treatment for staphylococci infections. The aim of our study is to identify the FA resistance situation at certain centers compared to generally increasing antibiotic resistance, to present epidemiological data on new antibiotherapy methods and to aid in treatment planning. Materials and methods: With this aim we determined and compared the susceptibility of 2018 Staphylococcus aureus and 5242 Coagulase negative Staphylococci strains obtained at 11 centers in different regions of our country against FA, oxacillin, penicillin, trimethoprim-sulfamethoxazole and ciprofloxacin. Results: The Coagulase negative Staphylococci strains were determined to be more resistant to all antibiotics compared to S. aureus strains. When the means of all centers are examined, FA resistance was found in 7.1% of S. aureus strains and 55.1% of Coagulase negative Staphylococci strains. Of all antibiotics for both S. aureus and Coagulase negative Staphylococci strains the antibiotic that strains were most susceptible to was trimethoprim-sulfamethoxazole, while the antibiotic that most were resistant to was penicillin. Conclusion: In light of these findings, with high susceptibility of 92.9% for S. aureus strains to FA, it appears to be a good alternative treatment choice for S. aureus infections. Due to high resistance rates of methicillin-resistant Coagulase negative Staphylococci sourced infections, before treatment it is necessary to perform an antibiotic susceptibility test. We believe that broader scale and more comprehensive studies will provide guidance in planning treatment.en_US
dc.identifier.doi10.19193/0393-6384_2018_2_63
dc.identifier.endpage402en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue2en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2018_2_63
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14075
dc.identifier.volume34en_US
dc.identifier.wosWOS:000429278400017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectThalasemia Traiten_US
dc.subjectIron Deficiency Anemiaen_US
dc.subjectDifferentiating Indexen_US
dc.subjectStaphylococci Sourced Infections
dc.subjectNew Antibiotherapy Methods
dc.subjectAntibiotic Resistance
dc.titleComparison of fusidic acid susceptibility of staphylococci: A multicenter studyen_US
dc.typeArticleen_US

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