Microwave-assisted ultra-fast synthesis of carbon quantum dots from linter: Fluorescence cancer imaging and human cell growth inhibition properties

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dc.authorid0000-0002-4523-6573en_US
dc.authorid0000-0003-4850-6927en_US
dc.authorid0000-0002-4204-9860en_US
dc.authorid0000-0003-2940-3172
dc.contributor.authorEskalen, Hasan
dc.contributor.authorUruş, Serhan
dc.contributor.authorCömertpay, Sabahattin
dc.contributor.authorKurt, Akif Hakan
dc.contributor.authorÖzgan, Şükrü
dc.date.accessioned2021-06-23T19:54:17Z
dc.date.available2021-06-23T19:54:17Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe water dispersed-fluorescent carbon quantum dots (CDs) were synthesized using microwave-assisted hydrothermal process in the closed system from the waste cotton linter as a new carbon source. This method provided an ultra-fast, more effective, economical and easier synthesis for cancer-imaging applications compared to the other methods presented in literature. The morphological and optical properties of the hydrothermally produced carbon quantum dots were characterized by using FT-IR, transmission electron microscopy (TEM), SEM, EDX, UV-vis and fluorescent spectrophotometry techniques. An emission peak was observed at 420 nm when the CDs were excited at 376 nm. CDs were calculated to have an average particle diameter of 10.14 nm by TEM. In order to determine the usability of the CDs in cell imaging, two different concentrations (50 mu L/mL and 100 mu L/mL) of the CDs colloidal solution were applied to a human mesothelioma cell line, H2452, and human umbilical vein endothelial cells (HUVEC) for varying durations. While the fluorescent photos revealed that 2 h of exposure was sufficient for the cells to take the C-dots in and higher concentrations appeared brighter in the wavelengths studied (red channel (excitation/emission 586/646 nm), blue channel (390/446 nm) and the green channel (482/532 nm)), cell viability and proliferation assays indicated that the material was cytotoxic against the both cell lines and inhibited the cell growth in a time- and dose- dependent manner.en_US
dc.identifier.doi10.1016/j.indcrop.2020.112209
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85079180686en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2020.112209
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10492
dc.identifier.volume147en_US
dc.identifier.wosWOS:000521513200011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKurt, Akif Hakan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofIndustrial Crops And Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrowaveen_US
dc.subjectFluorescenceen_US
dc.subjectCarbon Doten_US
dc.subjectLinteren_US
dc.subjectCancer Imagingen_US
dc.subjectCell Inhibitionen_US
dc.titleMicrowave-assisted ultra-fast synthesis of carbon quantum dots from linter: Fluorescence cancer imaging and human cell growth inhibition propertiesen_US
dc.typeArticleen_US

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