Asymetric dimethyl arginine level as a cardiovascular risk factor in patiens with hyperthyroidism

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dc.authorid0000-0002-3156-1076en_US
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorAlçelik, Ayşegül Gürses
dc.contributor.authorYalçın, Sübhan
dc.contributor.authorAydın, Yusuf
dc.date.accessioned2021-06-23T19:34:00Z
dc.date.available2021-06-23T19:34:00Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction. Thyroid diseases may cause endothelial dysfunction. Asymmetric dimethylarginine (ADMA) levels in patients with thyroid dysfunction were analyzed by few studies. Aim. We aimed to compare ADMA levels in patients with hyperthyroidism in a cohort free of cardiovascular risk associates such as diabetes or chronic renal failure with further comparison with healthy control subjects. Materials and methods. The study took place in Duzce University Medical Faculty, Cardiology and Internal Medicine Department during the year 2010. The study group consisted of patients with hyperthyroidism (overt and subclinical). The patients with renal failure, diabetes and severe hypertension were excluded. Results. Mean ADMA level was 1.04 +/- 0.43 mu mol/L in the hyperthyroid group and 0.68 +/- 0.21 mu mol/L in the control group (p <= 0.001). The comparison of patients with hyperthyroidism according to the etiology (three groups as Graves', multinodular goiter and thyroiditis) did not show any significant difference. Conclusion. Asymmetric dimethylarginine increases in patients with hyperthyroidism regardless of the etiology. The increase of ADMA levels is independent of known major cardiovascular risk factors. It may reflect the possible counteraction of endothelial dysfunction in the pathogenesis of atherosclerosis in hyperthyroidism beyond the known cardiovascular risk factors.en_US
dc.identifier.doi10.4183/aeb.2012.27
dc.identifier.endpage34en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84861021118en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=74184228&lang=tr&site=eds-live
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7333
dc.identifier.volume8en_US
dc.identifier.wosWOS:000302189400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAlçelik, Aytekin
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Dimethyl-Arginineen_US
dc.subjectHyperthyroidismen_US
dc.subjectCardiovascular Risken_US
dc.titleAsymetric dimethyl arginine level as a cardiovascular risk factor in patiens with hyperthyroidismen_US
dc.typeArticleen_US

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