Resveratrol inhibits nicotine-induced conditioned place preference in mice

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dc.authorid0000-0003-1075-9574en_US
dc.contributor.authorYunusoğlu, Oruç
dc.date.accessioned2023-08-09T07:07:14Z
dc.date.available2023-08-09T07:07:14Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractNicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4'-tetrahydroxystilbene) is the most well-known polyphenolic stilbenoid. Resveratrol was shown to exhibit positive effects on numerous mechanisms that are important for drug and substance addiction. Thus, this study aimed to examine the effect of resveratrol on nicotine addiction. Intraperitoneal (i.p.) treatment with nicotine (0.5 mg/kg) significantly enhanced time spent in the nicotine-paired compartment. Resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) co-administered with nicotine during the 3-day conditioning period effectively diminished the acquisition of nicotine-induced conditioned place preference (CPP). On the other hand, the administration of resveratrol (50 and 75 mg/kg, i.p.) and varenicline (2 mg/kg, i.p.) decreased the low dose (0.1 mg/kg, i.p.) nicotine-induced reinstatement. The results suggest that resveratrol and varenicline inhibit the acquisition and reinstatement of nicotine's reward properties. Resveratrol displayed similar results in the CPP phases as obtained with the reference drug varenicline. In conclusion, resveratrol could be beneficial as an adjuvant pharmacotherapy for nicotine addiction; however, more investigation is needed to completely explain this property.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Foundationen_US
dc.identifier.citationYunusoğlu, O. (2023). Resveratrol inhibits nicotine-induced conditioned place preference in mice. Brazilian Journal of Pharmaceutical Sciences, 59, e20883.en_US
dc.identifier.doi10.1590/s2175-97902023e20883
dc.identifier.endpage12en_US
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85158143415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1590/s2175-97902023e20883
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11460
dc.identifier.volume59en_US
dc.identifier.wosWOS:000975219400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNicotineen_US
dc.subjectResveratrolen_US
dc.subjectAcquisitionen_US
dc.subjectReinstatementen_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectNitric-Oxideen_US
dc.titleResveratrol inhibits nicotine-induced conditioned place preference in miceen_US
dc.typeArticleen_US

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