Evaluation of vitamin B12 level in middle-aged obese women with metabolic and nonmetabolic syndrome: Case-control study

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dc.authorid0000-0001-9967-5291
dc.authorid0000-0002-2926-7054
dc.contributor.authorBaltacı, Davut
dc.contributor.authorKutlucan, Ali
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorKarabulut, İsmail
dc.contributor.authorAk, Hayriye Yıldırım
dc.date.accessioned2021-06-23T18:40:25Z
dc.date.available2021-06-23T18:40:25Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: To investigate the correlation between vitamin B12 and body mass index (BMI) along with insulin resistance (IR) in middle-aged obese women. Materials and methods: Th e study was designed as a case-control study. Th e study group included middle-aged obese women and the control group included aged-matched lean women. Weight, height, and hip and waist circumferences were measured. Biochemical parameters such as fasting and postprandial glucose, vitamin B12 and folic acid levels, and lipid profi les were assayed. Results: Enrolled in the study were 116 middle-aged obese and 103 aged-matched healthy lean women. Th e vitamin B12 level of the obese women was signifi cantly lower than that of the lean women (244.1 ± 131.5 pg/mL vs. 336.2 ± 163.1 pg/mL, P = 0.002). However, there was no signifi cant diff erence in folic acid levels between the groups (P > 0.05). Th e vitamin B12 level was similar in the obese women with metabolic syndrome and those without (245.1 ± 145.3 pg/mL vs. 241.2 ± 96.5 pg/mL, P > 0.05), but the level in the control group was signifi cantly higher than that of patients with obesity and metabolic syndrome (P = 0.010 and P = 0.020, respectively). Vitamin B12 levels correlated with BMI (r = –0.259, P = 0.003) but not with IR (r = –0.053, P > 0.05). Conclusion: Th e vitamin B12 concentration was low in obese patients and this level negatively correlated with BMI, but not with homeostasis model assessment-estimated IR (HOMA-IR).en_US
dc.identifier.endpage809en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84864108000en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage802en_US
dc.identifier.trdizinid142000en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRReU1EQXdNQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3098
dc.identifier.volume42en_US
dc.identifier.wosWOS:000308053300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorÖztürk, Serkan
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectVitamin B12
dc.subjectİnsulin Resistance
dc.subjectBody Mass İndex
dc.subjectObezite
dc.subjectB12 Vitamini
dc.subjectİnsülin Direnci
dc.subjectVücut Kitle İndeksi
dc.titleEvaluation of vitamin B12 level in middle-aged obese women with metabolic and nonmetabolic syndrome: Case-control studyen_US
dc.typeArticleen_US

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