No association between polymorphisms of vitamin D and oxytocin receptor genes and autistic spectrum disorder in a sample of Turkish children

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dc.authorid0000-0001-9805-6624en_US
dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0002-2918-7871
dc.authorid0000-0003-3853-8212
dc.contributor.authorBozdoğan, Sevcan Tuğ
dc.contributor.authorKütük, Meryem Özlem
dc.contributor.authorTufan, Evren
dc.contributor.authorAltıntaş, Zuhal
dc.contributor.authorTemel, Gülhan Örekici
dc.date.accessioned2021-06-23T19:49:24Z
dc.date.available2021-06-23T19:49:24Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social skills and communication with repetitive behaviors. Etiology is still unclear although it is thought to develop with interaction of genes and environmental factors. Oxytocin has extensive effects on intrauterine brain development. Vitamin D, affects neural development and differentiation and contributes to the regulation of around 900 genes including oxytocin receptor gene. In the present study, the contribution of D vitamin receptor and oxytocin receptor gene polymorphisms in the development of ASD in Turkish community was investigated. To our knowledge, this is the first study examining these two associated genes together in the literature. Methods: Eighty-five patients diagnosed with ASD according to DSM-5 who were referred to outpatient clinics of Child and Adolescent Psychiatry of Baskent University and Mersin University and 52 healthy, age and gender-matched controls were included in the present study. Vitamin D receptor gene rs731236 (Taq1), rs2228570 (Fok1), rs1544410 (Bsm1), rs7975232 (Apa1) polymorphisms and oxytocin receptor gene rs1042778 and rs2268493 polymorphisms were investigated using real time polymerase chain reaction method. Results: No significant difference between groups in terms of distribution of genotype and alleles in each of polymorphisms for these genes could be found. Conclusion: Knowledge of genes and polymorphisms associated with the development of ASD may be beneficial for early diagnosis and future treatment. Further studies with larger populations are required to demonstrate molecular pathways which may play part in the development of ASD in Turkey.en_US
dc.identifier.doi10.9758/cpn.2018.16.4.415
dc.identifier.endpage421en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85055808243en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.2018.16.4.415
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9490
dc.identifier.volume16en_US
dc.identifier.wosWOS:000448050400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTufan, Evren
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology And Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutism Spectrum Disorderen_US
dc.subjectOxytocin Receptorsen_US
dc.subjectCalcitriol Receptorsen_US
dc.subjectGenetic Polymorphismen_US
dc.titleNo association between polymorphisms of vitamin D and oxytocin receptor genes and autistic spectrum disorder in a sample of Turkish childrenen_US
dc.typeArticleen_US

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