Identification of lactobacillus strains from breast-fed infant and investigation of their cholesterol-reducing effects

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dc.authorid0000-0002-4095-6619en_US
dc.authorid0000-0001-6906-5257
dc.authorid0000-0002-0595-7237
dc.contributor.authorYıldız, Gülgez Gökçe
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorAslım, Belma
dc.date.accessioned2021-06-23T19:27:39Z
dc.date.available2021-06-23T19:27:39Z
dc.date.issued2011
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractHypercholesterolemia has been reported to be the main cause of cardiovascular diseases and the leading cause of death. Therefore, decreasing serum cholesterol level is very important for preventing the cardiovascular diseases. It has been supposed that probiotics in human gastrointestinal tract have the ability to decrease serum cholesterol level by reducing the absorption of cholesterol from the intestinal tract and the bile salt deconjugation. In this study, 28 strains of Lactobacillus spp., isolated from breast-fed infant's feces, were identified and investigated for their bile salt deconjugation ability. The deconjugation ability of the strains was determined by the release of cholic acid resulting from the deconjugation of conjugated bile salts. Research results showed that four of the strains had bile salt deconjugation ability. The strains with deconjugation ability have been identified in species level by using biochemical test, and molecular techniques, API 50CHL test and 16S rRNA gene sequence analysis respectively. LP1, E3, and E9 strains with deconjugation activity were identified as Lactobacillus rhamnosus and GD2 strain as Lactobacillus plantarum. Even if oxgall decreases the viability of bacteria, the highest amount of cholesterol precipitation (42%) was performed by GD2 strain in the presence of 0.3% (w/v) bile. This study demonstrated that the identified Lactobacillus strains had an excellent ability to survive at low pH, a high bile deconjugation ability, and hypocholesterolemic effect in in vitro conditions.en_US
dc.identifier.doi10.1007/s11274-011-0710-x
dc.identifier.endpage2406en_US
dc.identifier.issn0959-3993
dc.identifier.issn1573-0972
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-80052863928en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2397en_US
dc.identifier.urihttps://doi.org/10.1007/s11274-011-0710-x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6864
dc.identifier.volume27en_US
dc.identifier.wosWOS:000294966900019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYıldız, Gülgez Gökçe
dc.institutionauthorÖztürk, Mehmet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofWorld Journal Of Microbiology & Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLactobacillus Spp.en_US
dc.subjectDeconjugation Abilityen_US
dc.subjectCholesterolen_US
dc.subjectBSH Activityen_US
dc.titleIdentification of lactobacillus strains from breast-fed infant and investigation of their cholesterol-reducing effectsen_US
dc.typeArticleen_US

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