Plasma levels of neurogenic inflammation related neuropeptides in pediatric patients with community-acquired pneumonia and their potential diagnostic value in distinguishing viral and bacterial pneumonia

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dc.authoridBaranoglu Kilinc, Yasemin/0000-0002-1795-5677
dc.authoridKilinc, Erkan/0000-0001-9261-2634
dc.authoridBekdas, Mervan/0000-0003-2469-9509
dc.contributor.authorBekdas, Mervan
dc.contributor.authorSaygi, Bilgi
dc.contributor.authorKilinc, Yasemin Baranoglu
dc.contributor.authorKilinc, Erkan
dc.date.accessioned2024-09-25T19:57:27Z
dc.date.available2024-09-25T19:57:27Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractNeurogenic inflammation is involved in the development and progression of respiratory inflammatory diseases. However, its role in community-acquired pneumonia (CAP) remains unclear. We therefore aimed to investigate plasma levels of neurogenic inflammation-related neuropeptides, calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY), and procalcitonin (PCT) in pediatric patients with CAP and to assess their diagnostic value in viral and bacterial/mixed pneumonia. A total of 124 pediatric patients with CAP (1 month-18 years old) and 56 healthy children of similar ages were prospectively enrolled. The patients were classified as viral (n = 99) and bacterial/mixed (n = 25) pneumonia. Plasma levels of the peptides were quantified by ELISA. ROC analysis was performed to evaluate possible diagnostic value of the peptides. While plasma levels of CGRP, VIP and PCT were significantly higher in patients with CAP than in the control group, respectively, NPY levels were significantly lower. Moreover, plasma levels of all neuropeptides and PCT were significantly higher in bacterial pneumonia patients compared to viral pneumonia patients. ROC analysis revealed that CGRP, SP and NPY had a diagnostic value in distinguishing viral and bacterial/mixed pneumonia.Conclusions: Our findings suggest that these neuropeptides may be implicated in pediatric CAP. CGRP, SP and NPY together may be a promising candidate in distinguishing viral and bacterial/mixed pneumonia, however, for this, further studies are needed.What is Known:center dot Neurogenic inflammation contributes to the development and progression of respiratory inflammatory diseases such as chronic obstructive pulmonary disease and bronchial asthma.What is New:center dot Plasma levels of neurogenic inflammation related neuropeptides calcitonin gene-related peptide, substance P, vasoactive intestinal peptide and neuropeptide Y are changed in pediatric community-acquired pneumonia. Calcitonin gene-related peptide, substance P and neuropeptide Y are promising candidates in distinguishing viral and bacterial/mixed pneumonia.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal Universityen_US
dc.description.sponsorshipWe thank the children and their parents who participated in the study.en_US
dc.identifier.doi10.1007/s00431-023-05417-y
dc.identifier.endpage1627en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue4en_US
dc.identifier.pmid38183438en_US
dc.identifier.scopus2-s2.0-85181502389en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1619en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-023-05417-y
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13430
dc.identifier.volume183en_US
dc.identifier.wosWOS:001137214200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCommunity-acquired pneumoniaen_US
dc.subjectChildrenen_US
dc.subjectNeurogenic inflammationen_US
dc.subjectNeuropeptidesen_US
dc.titlePlasma levels of neurogenic inflammation related neuropeptides in pediatric patients with community-acquired pneumonia and their potential diagnostic value in distinguishing viral and bacterial pneumoniaen_US
dc.typeArticleen_US

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