Gold-modified molecularly imprinted N-methacryloyl-(l)-phenylalanine-containing electrodes for electrochemical detection of dopamine

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dc.authorid0000-0002-6672-6862en_US
dc.authorid0000-0003-4037-3445en_US
dc.authorid0000-0001-7292-7241en_US
dc.authorid0000-0003-0161-172Xen_US
dc.authorid0000-0003-3260-1639en_US
dc.authorid0000-0001-7548-5741en_US
dc.contributor.authorShama, Nemah Abu
dc.contributor.authorAşır, Süleyman
dc.contributor.authorÖzsöz, Mehmet
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorTürkmen, Deniz
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-01-12T06:59:06Z
dc.date.available2024-01-12T06:59:06Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractA molecularly imprinted polymer-based pencil graphite electrode (MIP PGE) sensor, modified with gold nanoparticles, was utilized for the detection of dopamine in the presence of other biochemical compounds using cyclic voltammetry (CV) and differential pulse voltammetry (DPV), depending on its strong electroactivity function. The pulse voltammetry methods recorded the highest response. In addition to the high oxidation rate of DA and the other biomolecule interferences available in the sample matrix used, which cause overlapping voltammograms, we aimed to differentiate them in a highly sensitive limit of detection range. The calibration curves for DA were obtained using the CV and DPV over the concentration range of 0.395-3.96 nM in 0.1 M phosphate buffer solution (PBS) at pH 7.4 with a correlation coefficient of 0.996 and a detection limit of 0.193 nM. The electrochemical technique was employed to detect DA molecules quantitatively in human blood plasma selected as real samples without applying any pre-treatment processes. MIP electrodes proved their ability to detect DA with high selectivity, even with epinephrine and norepinephrine competitor molecules and interferences, such as ascorbic acid (AA). The high level of recognition achieved by molecularly imprinted polymers (MIPs) is essential for many biological and pharmaceutical studies.en_US
dc.identifier.citationAbu Shama, N., Aşır, S., Ozsoz, M., Göktürk, I., Türkmen, D., Yılmaz, F., & Denizli, A. (2022). Gold-modified molecularly imprinted N-Methacryloyl-(L)-phenylalanine-containing electrodes for electrochemical detection of dopamine. Bioengineering, 9(3), 87.en_US
dc.identifier.doi10.3390/bioengineering9030087
dc.identifier.endpage16en_US
dc.identifier.issn2306-5354
dc.identifier.issue3en_US
dc.identifier.pmid35324776en_US
dc.identifier.scopus2-s2.0-85125443151en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.3390/bioengineering9030087
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11926
dc.identifier.volume9en_US
dc.identifier.wosWOS:000775808700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBioengineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDopamineen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectPencil Graphite Electrodeen_US
dc.subjectMolecularly Imprinted Polymeren_US
dc.subjectDifferential Pulse Voltammetryen_US
dc.subjectCyclic Voltammetryen_US
dc.titleGold-modified molecularly imprinted N-methacryloyl-(l)-phenylalanine-containing electrodes for electrochemical detection of dopamineen_US
dc.typeArticleen_US

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