Genetic insights into bladder cancer: the impact of SIRT1 gene polymorphism

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dc.contributor.authorBostanci, Emre
dc.contributor.authorKirkik, Duygu
dc.contributor.authorKalkanli Tas, Sevgi
dc.contributor.authorUyeturk, Ugur
dc.date.accessioned2024-09-25T19:56:32Z
dc.date.available2024-09-25T19:56:32Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBladder cancer (BC) has shown a significant global health concern with distinct pathological, genetic, and epigenetic characteristics. Its prevalence is influenced by various risk factors, including age, gender, and genetic predisposition. This study investigates the association between BC and the Sirtuin 1 (SIRT1) gene polymorphism rs369274325 in the Turkish population. Genomic DNA was isolated from peripheral blood samples and genotyping of rs369274325 polymorphism in SIRT 1 was investigated in 200 individuals (in 100 Turkish bladder cancer patients and 100 healthy individuals as the control group.) by real-time PCR. Demographic information, smoking and alcohol consumption status was analyzed by statistical analysis. Statistical analysis was performed by Pearson's Chi-square test. Smoking and alcohol consumption were significantly higher in BC patients compared to controls (p < 0.00018 and p < 0.0001, respectively). The genotypic distribution of SIRT1 rs369274325 did not show a significant difference between BC patients and controls (p = 0.5550). BC, influenced by genetic and environmental factors, has been linked to various gene mutations. SIRT1, involved in diverse physiological processes, is proposed to play a role in BC. However, our study did not find a significant association between SIRT1 rs369274325 polymorphism and BC in the Turkish population.en_US
dc.description.sponsorshipAbant Izzet Baysal University Scientific Research Projects (BAP) [2021.08.20.1500]en_US
dc.description.sponsorshipThe project was supported by the Abant Izzet Baysal University Scientific Research Projects (BAP) number: 2021.08.20.1500.en_US
dc.identifier.doi10.1080/15257770.2024.2310710
dc.identifier.issn1525-7770
dc.identifier.issn1532-2335
dc.identifier.pmid38305254en_US
dc.identifier.scopus2-s2.0-85184265463en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/15257770.2024.2310710
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13327
dc.identifier.wosWOS:001156506000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofNucleosides Nucleotides & Nucleic Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectBladder canceren_US
dc.subjectSIRT1 gene polymorphismen_US
dc.subjectgenetic aspectsen_US
dc.subjectrs369274325 a/Gen_US
dc.titleGenetic insights into bladder cancer: the impact of SIRT1 gene polymorphismen_US
dc.typeArticleen_US

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