CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients

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dc.authoridKurt, Emine Bahar
dc.authoridİşcan, Mümtaz
dc.authorid0000-0001-9987-0572
dc.authorid0000-0002-3495-2339
dc.contributor.authorAda, Ahmet Oğuz
dc.contributor.authorKunak, Celalettin Semih
dc.contributor.authorBilgen, Serdar
dc.contributor.authorAlpar, Sibel
dc.contributor.authorGülhan, Meral
dc.date.accessioned2021-06-23T18:52:01Z
dc.date.available2021-06-23T18:52:01Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSeveral polymorphisms in cytochrome P-450s (CYP)s and Glutathione S-transferases (GST)s have been reported to be associated with survival rates of patients with non-small cell lung cancer (NSCLC) but the studies in this regard are scarce and the results are contradictory. In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Ala114Val) and GSTT1 polymorphisms were determined in 138 patients with advanced NSCLC to evaluate their role in survival. Of the studied CYP and GST polymorphisms only GSTP1 exon 6 variant significantly altered (improved) the survival compared to wild type (p=0.036) with median survival of 22.2 months and 16.1 months, respectively. Multivariate analysis also revealed a significant reduction of adjusted hazard ratio of death associated only with the GSTP1 exon 6 variant genotype of 0.45 (95% confidence interval (95% CI), 0.23-0.89, p=0.022). These results show that the GSTP1 exon 6 variant genotype is associated with improved survival in the patients with advanced NSCLC.en_US
dc.identifier.doi10.4149/neo_2010_06_512
dc.identifier.endpage521en_US
dc.identifier.issn0028-2685
dc.identifier.issue6en_US
dc.identifier.pmid20845989en_US
dc.identifier.scopus2-s2.0-79952113910en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage512en_US
dc.identifier.urihttps://doi.org/10.4149/neo_2010_06_512
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4097
dc.identifier.volume57en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Emine Bahar
dc.language.isoenen_US
dc.publisherSAP - Slovak Academic Press, spol. s.r.o.en_US
dc.relation.ispartofNeoplasmaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytochrome P-450en_US
dc.subjectGlutathione S-Transferaseen_US
dc.subjectNon Small Cell Lung Canceren_US
dc.subjectPolymorphismen_US
dc.subjectSurvivalen_US
dc.titleCYP and GST polymorphisms and survival in advanced non-small cell lung cancer patientsen_US
dc.typeArticleen_US

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Scopus İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu