The therapeutic effects of etanercept-methotrexate combination on experimental spinal cord injury.

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dc.authorid0000-0002-3260-7419en_US
dc.authorid0000-0002-1668-7850
dc.authorid0000-0002-8317-7092
dc.contributor.authorGezici, Ali Rıza
dc.contributor.authorAkar, Semih
dc.contributor.authorFırat, Tülin
dc.contributor.authorDağıstan, Yaşar
dc.contributor.authorCancan, Seçkin Emre
dc.date.accessioned2021-06-23T19:49:15Z
dc.date.available2021-06-23T19:49:15Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Experimental studies have demonstrated that neurons keep dying in an unrecoverable and non-regenerative pattern in following hours after primary mechanical injury to spinal cord. The cascade of events which is called secondary injury is composed of vascular impairment, oedema, ischemia, inflammation, exotoxicity, electrolyte imbalance, lipid peroxidation, free radicals, necrosis and apoptotic cell death. Aims: With clinical and histopathological tests, this study investigated the therapeutic effects of etanercept-methotrexate combination which is an option in mono-therapy resistant rheumatological diseases; but this combination has not been used on recovery processes in clip compression Spinal Cord Injury (SCI) model yet. Study design: Forty Spraque-Dawley rats were divided into five groups: group 1 (Sham-control), group 2 (SCI+2 ml saline intramuscular), group 3 (SCI+1.25 mg/kg etanercept), group 4 (SCI+0.5 mg/kg methotrexate) and group 5 (SCI+1.25 mg/kg etanercept+0.5 mg/kg methotrexate). Methods: Rats were evaluated 1st, 3rd, 5th and 10th days after SCI, clinically by Drummond and Moore scale, under light microscopy and by Tunel test; after sacrification on 10th day. Results: Clinical and histopathological results of all treatment groups were found significantly better than the results of the trauma group; also no superiority in the monotherapy groups, over each other, was noted. Conclusion: Combined-treatment group had a statistically significant better outcome in preventing apoptosis, but there was no difference according to the clinical results.en_US
dc.identifier.endpage2192en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2185en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9430
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000396838200049
dc.identifier.volume28en_US
dc.identifier.wosWOS:000396838200049en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGezici, Ali Rıza
dc.institutionauthorAkar, Semih
dc.institutionauthorFırat, Tülin
dc.institutionauthorDağıstan, Yaşar
dc.institutionauthorCancan, Seçkin Emre
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectEtanercepten_US
dc.subjectMethotrexateen_US
dc.titleThe therapeutic effects of etanercept-methotrexate combination on experimental spinal cord injury.en_US
dc.typeArticleen_US

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