Serum apolipoprotein B is superior to LDL-cholesterol level in predicting incident coronary disease among Turks

Basit Öğe Kaydı
dc.contributor.authorOnat, Altan
dc.contributor.authorOzhan, Hakan
dc.contributor.authorCan, Guenay
dc.contributor.authorHergenc, Guelay
dc.contributor.authorKarabulut, Ahmet
dc.contributor.authorAlbayrak, Sinan
dc.date.accessioned2024-09-25T19:56:08Z
dc.date.available2024-09-25T19:56:08Z
dc.date.issued2007
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: To investigate the relative roles of serum apolipoprotein (apo) B and low density lipoprotein (LDL)-cholesterol levels in predicting incident coronary heart disease (CHID). Whether apo B/apo A-I ratio has advantage over apo B in this prediction constitutes a secondary aim. Methods: Prospective evaluation of 1138 men and 1210 women, aged 28-74 years participating in the TEKHARF survey 1997/98 with a mean 5.9-years' follow-up in whom serum apo B was determined. Tertiles of LDL-cholesterol were formed by cut points of 130 and 100 mg/dl, and of apo B by 120 and 95 mg/dl. Metabolic syndrome was defined by modified ATPIII criteria. Nonfatal CHD diagnosis was based on history of angina and myocardial revascularization, physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms. Results: Apolipoprotein B showed significant correlations with a greater number of parameters than did LDL-cholesterol. Incident CHID was not significantly predicted in age-adjusted logistic regression by LDL-cholesterol but by apo B concentrations in men with a relative risk (RR) 1.005. Apolipoprotein B level >120 vs <95 mg/dl retained significance in both genders combined, even after adjustment for waist girth and log C-reactive protein. The top (>1.02) compared with the bottom bracket of apo B/A-I ratio, though not reaching significantly predictive values among women, did significantly predict in men incident CHID with a RR 1.89. Conclusions: Apolipoprotein B, which marks small, dense LDL particles in plasma is a better predictor of incident CHID than LDL-cholesterol among Turkish adults. While in the prediction of CHID apo B level should be preferred in women, an apo B/A-I ratio >11.02 has advantages over the latter in men. It is time to create the environment (at least in our cities) for measuring in equipped laboratories apo B, which has advantages over measurements that permit calculation of LDL-cholesterol.en_US
dc.identifier.endpage133en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue2en_US
dc.identifier.pmid17513206en_US
dc.identifier.scopus2-s2.0-34250019971en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13132
dc.identifier.volume7en_US
dc.identifier.wosWOS:000254243500004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectabdominal obesityen_US
dc.subjectapolipoprotein A-I and Ben_US
dc.subjectcoronary heart disease risken_US
dc.subjectTurkish adultsen_US
dc.subjectLDL-cholesterolen_US
dc.subjectTurkish Adult Risk Factor studyen_US
dc.titleSerum apolipoprotein B is superior to LDL-cholesterol level in predicting incident coronary disease among Turksen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu