A comparison of clinical characteristics and course predictors in early- and childhood-onset schizophrenia

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dc.authoridCobanoglu Osmanli, Cansu/0000-0002-9631-1262
dc.authoridBozkurt, abdullah/0000-0002-8359-6131
dc.authoridHangul, Zehra/0000-0001-8397-5636
dc.authoridOnal, Bedia Sultan/0000-0003-2818-4764
dc.authoridAYAYDIN, Hamza/0000-0003-4909-0070
dc.authoridSahin, Berkan/0000-0003-4699-3418
dc.contributor.authorBaykal, Saliha
dc.contributor.authorBozkurt, Abdullah
dc.contributor.authorcobanoglu Osmanli, Cansu
dc.contributor.authorOnal, Bedia Sultan
dc.contributor.authorSahin, Berkan
dc.contributor.authorKaradogan, Zeynep Nur
dc.contributor.authorKaradag, Mehmet
dc.date.accessioned2024-09-25T19:57:25Z
dc.date.available2024-09-25T19:57:25Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAimThe aim of this study was to compare the clinical characteristics of childhood-onset schizophrenia (COS) and early-onset schizophrenia (EOS) during the first- episode psychosis and the stable period, to examine psychopharmacological treatment approaches, and to investigate potential predictive factors for prognosis.MethodsDemographic, clinical, and psychopharmacological therapy data for 31 patients diagnosed with COS and 66 with EOS were retrieved from the file records in this multicenter study. Symptom distribution and disease severity and course were evaluated twice, in the acute psychotic stage and in the latest stable phase, during follow-up using the positive and negative syndrome scale (PANSS) and clinical global impression (CGI) scales.ResultsA statistically significant difference was observed between the groups' CGI improvement rates and median last stable stage PANSS positive, negative, and general psychopathology symptom scores (p = .005, p = .031, p = .005, and p = .012, respectively). Premorbid neurodevelopmental disorder and obsessive-compulsive disorder and comorbidities were more common in the COS group (p = .025 and p = .030, respectively), and treatment required greater multiple antipsychotic use in that group (p = .013). When the independent variables affecting the difference between pre- and post-treatment PANSS scores were examined using linear regression analysis, the model established was found to be statistically significant (F = 5.393; p = .001), and the group variable (p = .024), initial disease severity (p = .001), and socioeconomic level (p = .022; p = .007) emerged as predictive factors for the disease course.ConclusionAlthough early diagnosis and treatment is an important factor in improving prognosis in schizophrenia, more specific predictors for schizophrenia need to be identified. Additionally, preventive programs and pharmacological methods need to be developed in children with neurodevelopmental problems, particularly those from low socioeconomic status families.en_US
dc.description.sponsorshipThe authors thank the patients and their families who participated in the study.en_US
dc.identifier.doi10.1111/eip.13594
dc.identifier.issn1751-7885
dc.identifier.issn1751-7893
dc.identifier.pmid38992332en_US
dc.identifier.scopus2-s2.0-85198378306en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/eip.13594
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13405
dc.identifier.wosWOS:001268909300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHangul, Zehra
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEarly Intervention in Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectchildhood onset schizophreniaen_US
dc.subjectclinical featuresen_US
dc.subjectcomorbiditiesen_US
dc.subjectearly onset schizophreniaen_US
dc.subjectpatient outcome assessmenten_US
dc.subjectpsychopharmacologyen_US
dc.titleA comparison of clinical characteristics and course predictors in early- and childhood-onset schizophreniaen_US
dc.typeArticleen_US

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