Deteriorated thiol-disulphide and oxidized-reduced glutathione status in blood in Alzheimer's disease

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dc.contributor.authorAkunal, Canan
dc.contributor.authorAlisik, Murat
dc.date.accessioned2024-09-25T19:56:14Z
dc.date.available2024-09-25T19:56:14Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Alzheimer's disease (AD) is a steadily advancing neurodegenerative condition, the occurrence and prevalence of which are on the rise in various populations. Suspected factors contributing to its development encompass the buildup of amyloid (3 (A(3) plaques, the formation of neurofibrillary tangles induced by tau proteins, and heightened oxidative stress. In this study, we aimed to evaluate intra-cellular glutathione status and extracellular thiol-disulphide status in patients with AD. Methods: Adult patients (>60 years old) diagnosed with AD based on DSM-IV diagnostic criteria were included in the study. Patients were divided into 3 groups as mild, moderate and severe according to Mini Mental Status Examination (MMSE) and clinical findings. Extracellular thiol-disulfide and intracellular oxidized-reduced glutathione status parameters for patient and control groups were analyzed before and after reduction procedures by using reaction of thiol groups with DTNB. Results: The reduced forms of both balances (native thiol (NT) and reduced glutathione (GSH)) were significantly lower in the patient group than the control group (p = 0.031 and <0.001, respectively), while oxidized forms (disulphide (SS) and oxidized glutathione (GSSG)) and SS/NT and GSSG/GSH percent ratios were significantly higher (p < 0.05 for all). The disease duration and oxidative stress were significantly higher in the severe group of AD. There was a shift in intracellular and extracellular thiol balances towards the oxidized side, along with correlations between MMSE and these balances (rho = -0.412 for SS/NT and rho = -0.488 for GSSG/GSH), with GSSG/GSH identified as a significant predictive factor (odds ratio (95 % confidence interval): 1.352 (1.136-1.610) for the moderate group and 1.829 (1.451-2.305) for the severe group. Conclusions: These findings suggest that blood redox balance is disrupted in AD.en_US
dc.description.sponsorshipFunding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.en_US
dc.identifier.doi10.1016/j.clinbiochem.2024.110817
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.pmid39260810en_US
dc.identifier.scopus2-s2.0-85203439550en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2024.110817
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13204
dc.identifier.volume133-134en_US
dc.identifier.wosWOS:001313949400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectOxidative stressen_US
dc.subjectMMSEen_US
dc.subjectDisulfidesen_US
dc.subjectThiol-disulphide homeostasisen_US
dc.titleDeteriorated thiol-disulphide and oxidized-reduced glutathione status in blood in Alzheimer's diseaseen_US
dc.typeArticleen_US

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