The efficiency of two-dose hepatitis B vaccination in health care workers for immunoprophylaxis

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dc.authorid0000-0003-1514-1685
dc.authorid0000-0003-2005-0737
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorTamer, Ali
dc.contributor.authorKoç İnce, Nevin
dc.contributor.authorBüyükahraz, Nisa
dc.contributor.authorVardı, Şeref
dc.date.accessioned2021-06-23T18:54:20Z
dc.date.available2021-06-23T18:54:20Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Previous studies showed that 2 dose vaccinations 4 months apart were as effective as 3 dose vaccination schedules. In this study, we aimed to investigate the reliability and efficiency of 2 doses of Hepatitis B vaccine in health care workers. Material and Methods: Two dose and 3 dose vaccination groups who were negative for HBsAg, anti-HBcIgG and anti-HBs were selected among health care workers working in the İzzet Baysal Medical Faculty and were randomized in a 1:1 ratio. The 2 dose group included 36 subjects and 33 subjects were present in the 3 dose group. The 2 dose group was vaccinated with 20 ?g of vaccine at 0 and 4 months and the same dose was administered to the 3 dose group at 0, 1, and 6 months. Geometric Mean Titers (GMT) were calculated by measuring the level of anti-HBs quantitatively 2 months after the last shot in both groups. Results: GMT values of the 2 and 3 dose groups were determined as 314.5 and 599.2 IU/mL, respectively (p< 0.01). While the number of subjects with antibody titers under the protective level (anti-HBs<10 IU/mL) was 11 in the 2 dose group, only 1 patient in the 3 dose group had low antibody levels at the end of the vaccination schedule (p< 0.05). No significant difference was observed in terms of adverse effects between the 2 groups (p> 0.05). Conclusion: Although encouraging results were obtained in recent studies, the 2 dose vaccination schedule at 0 and 4 months used in our study for hepatitis B prophylaxis in health care workers was not as effective as the standard schedule. Thus, larger studies are required. Copyright © 2006 by Türkiye Klinikleri.en_US
dc.identifier.endpage28en_US
dc.identifier.issn1300-0292
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-33144458848en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4379
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33144458848&partnerID=40&md5=eb572cfc869ffb58edb1be3026e9d096
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKarabay, Oğuz
dc.institutionauthorTamer, Ali
dc.institutionauthorKoç İnce, Nevin
dc.institutionauthorBüyükahraz, Nisa
dc.institutionauthorVardı, Şeref
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectVaccinationen_US
dc.titleThe efficiency of two-dose hepatitis B vaccination in health care workers for immunoprophylaxisen_US
dc.title.alternativeSa?lık çalışanlarına profilaksi amacıyla uygulanan i?ki dozluk hepatit B aşisının etkinli?inin ara?tırılmasıen_US
dc.typeArticleen_US

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