The efficiency of two-dose hepatitis B vaccination in health care workers for immunoprophylaxis
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Previous studies showed that 2 dose vaccinations 4 months apart were as effective as 3 dose vaccination schedules. In this study, we aimed to investigate the reliability and efficiency of 2 doses of Hepatitis B vaccine in health care workers. Material and Methods: Two dose and 3 dose vaccination groups who were negative for HBsAg, anti-HBcIgG and anti-HBs were selected among health care workers working in the İzzet Baysal Medical Faculty and were randomized in a 1:1 ratio. The 2 dose group included 36 subjects and 33 subjects were present in the 3 dose group. The 2 dose group was vaccinated with 20 ?g of vaccine at 0 and 4 months and the same dose was administered to the 3 dose group at 0, 1, and 6 months. Geometric Mean Titers (GMT) were calculated by measuring the level of anti-HBs quantitatively 2 months after the last shot in both groups. Results: GMT values of the 2 and 3 dose groups were determined as 314.5 and 599.2 IU/mL, respectively (p< 0.01). While the number of subjects with antibody titers under the protective level (anti-HBs<10 IU/mL) was 11 in the 2 dose group, only 1 patient in the 3 dose group had low antibody levels at the end of the vaccination schedule (p< 0.05). No significant difference was observed in terms of adverse effects between the 2 groups (p> 0.05). Conclusion: Although encouraging results were obtained in recent studies, the 2 dose vaccination schedule at 0 and 4 months used in our study for hepatitis B prophylaxis in health care workers was not as effective as the standard schedule. Thus, larger studies are required. Copyright © 2006 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Hepatitis B, Vaccination
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
26
Sayı
1
