Synthesis, potentiometric and antimicrobial activity studies on 2-pyridinilidene-DL-amino acids and their complexes

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dc.authorid0000-0002-4764-7747
dc.authorid0000-0002-0625-2482
dc.authorid0000-0002-2478-6875
dc.contributor.authorSarı, Nurşen
dc.contributor.authorGürkan, Perihan
dc.contributor.authorArslan, Seza
dc.date.accessioned2021-06-23T19:17:38Z
dc.date.available2021-06-23T19:17:38Z
dc.date.issued2003
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractTo investigate the relationship between antimicrobial activities and the formation constants of Cu-II, Ni-II and Co-II complexes with three Schiff bases, which were obtained by the condensation of 2-pyridinecarboxyaldehyde with DL-alanine, DL-valine and DL-phenylalanine, have been synthesized. Schiff bases and the complexes have been characterized on the basis of elemental analyses, magnetic moments (at ca. 25 degreesC), molar conductivity, thermal analyses and spectral (i.r., u.v., n.m.r.) studies. The i.r. spectra show that the ligands act in a monovalent bidentate fashion, depending on the metal salt used and the reaction pH = 9, 8 and 7 medium, for Cu-II, Ni-II and Co-II, respectively. Square-planar, tetrahedral and octahedral structures are proposed for Cu-II, Ni-II and Co-II, respectively. The protonation constants of the Schiff bases and stability constants of their ML-type complexes have been calculated potentiometrically in aqueous solution at 25 +/- 0.1 degreesC and at 0.1 M KCl ionic strength. Antimicrobial activities of the Schiff bases and the complexes were evaluated for three bacteria (Bacillus subtillis, Staphylococcus aureus, and Escherichia coli) and a yeast (Candida albicans). The structure-activity correlation in Schiff bases and their metal(II) complexes are discussed, based on the effect of their stability contants.en_US
dc.identifier.doi10.1023/A:1023685719951
dc.identifier.endpage474en_US
dc.identifier.issn0340-4285
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0037526286en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage468en_US
dc.identifier.urihttps://doi.org/10.1023/A:1023685719951
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5490
dc.identifier.volume28en_US
dc.identifier.wosWOS:000182710000017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorArslan, Seza
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTransition Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSynthesisen_US
dc.subjectPotentiometric
dc.subjectAntimicrobial
dc.subjectPyridinilidene
dc.subjectAmino Acids
dc.titleSynthesis, potentiometric and antimicrobial activity studies on 2-pyridinilidene-DL-amino acids and their complexesen_US
dc.typeArticleen_US

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