Epithelialization process of free fascial flaps used in reconstruction of oral cavity mucosa defects in dogs

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dc.authorid0000-0002-2051-1049
dc.authorid0000-0002-8678-1797
dc.authorid0000-0002-4257-0672
dc.contributor.authorUğurlu, Kemal
dc.contributor.authorHüthüt, İlkay
dc.contributor.authorÖzçelik, Derya
dc.contributor.authorÖzer, Kürşat
dc.contributor.authorSakız, Damlanur
dc.contributor.authorYıldız, Kemalettin
dc.contributor.authorBaş, Lütfü
dc.date.accessioned2021-06-23T19:18:03Z
dc.date.available2021-06-23T19:18:03Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBare free fascial flaps are increasingly used for restoration of soft-tissue defects of the oral cavity because they provide thin, foldable tissues with high epithelialization capacity to preserve local anatomy as well as chewing, phonation, and deglutition. However, there are unanswered questions regarding the epithelialization process and other histopathologic changes occurring after transfer of these flaps into the oral cavity. To investigate these changes thoroughly, an experimental study was conducted in the dog model. Bare dorsal thoracic fascia was used as the free flap model. Ten adult dogs were used in this experiment. Oral mucosa defects measuring 6 x 5 cm were created. Free dorsal thoracic fascia flaps were harvested. The vascular pedicle of the fascia flap was anastomosed with the superior thyroidal artery and external jugular vein. Then, the flaps were transferred into the mucosa defects. The dogs were divided into groups, each composed of two animals. At 7, 14, 21, 30, and 60 days postoperatively, general anesthesia was administered to the groups 1, 2, 3, 4, and 5, respectively. First, clinical assessment was performed; then specimens were obtained. Initially, the flaps were gradually infiltrated by acute inflammatory cells coming from the circulation and then replaced by granulation tissue. Epithelial cells deriving from wound margins migrated onto the granulating flaps with eventual coverage of highly organized epithelium after 4 weeks, and the fascia flap could not be differentiated from the native mucosa. The flaps were replaced by normally maturated fibrous tissue containing regular collagen fibers, instead of atypical scar tissue. Wound contraction was calculated as 18 percent at postoperativc day 60. It was detected that bare free fascia flaps used in the repair of mucosa defects act as a scaffold and complete epithelialization from surrounding margins. They can be accepted as the main surgical option for the reconstruction of oral cavity mucosa defects.en_US
dc.identifier.doi10.1097/01.PRS.0000105625.27802.64
dc.identifier.endpage923en_US
dc.identifier.issn0032-1052
dc.identifier.issue3en_US
dc.identifier.pmid15108883en_US
dc.identifier.startpage915en_US
dc.identifier.urihttps://doi.org/10.1097/01.PRS.0000105625.27802.64
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5625
dc.identifier.volume113en_US
dc.identifier.wosWOS:000220063500017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzer, Kürşat
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPlastic And Reconstructive Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpithelializationen_US
dc.subjectReconstruction
dc.subjectOral Cavity
dc.subjectMucosa Defects
dc.subjectFree Fascial Flaps
dc.titleEpithelialization process of free fascial flaps used in reconstruction of oral cavity mucosa defects in dogsen_US
dc.typeArticleen_US

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